{"id":"risedronate-cholecalciferol-combination","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal irritation (esophageal, gastric)"},{"rate":null,"effect":"Musculoskeletal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hypercalcemia (with excessive vitamin D)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Risedronate is a bisphosphonate that binds to hydroxyapatite in bone and inhibits farnesyl pyrophosphate synthase in osteoclasts, reducing bone turnover. Cholecalciferol (vitamin D3) increases intestinal calcium absorption and promotes bone mineralization, complementing the antiresorptive effect of risedronate. Together, they work synergistically to increase bone mineral density and reduce fracture risk.","oneSentence":"Risedronate inhibits bone resorption by blocking osteoclast activity, while cholecalciferol (vitamin D3) enhances calcium absorption and supports bone mineralization.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:05:15.812Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoporosis in postmenopausal women"},{"name":"Osteoporosis in men"},{"name":"Glucocorticoid-induced osteoporosis"}]},"trialDetails":[{"nctId":"NCT07242612","phase":"NA","title":"Bone Turnover Markers and Treatment Efficacy in Postmenopausal Osteoporosis","status":"RECRUITING","sponsor":"Khyber Medical University Peshawar","startDate":"2025-10-01","conditions":"Osteoporosis, Osteoporosis, Postmenopausal","enrollment":40},{"nctId":"NCT05630768","phase":"PHASE4","title":"Efficacy and Safety of Actonel® After Denosumab Discontinuation in Postmenopausal Osteoporosis Women","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2023-01-03","conditions":"Postmenopausal Osteoporosis","enrollment":149},{"nctId":"NCT00567606","phase":"NA","title":"Prevention of Osteoporosis in Breast Cancer Survivors","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2002-04-01","conditions":"Postmenopausal Osteoporosis","enrollment":249},{"nctId":"NCT01675297","phase":"PHASE4","title":"Efficacy and Safety Study of Risedronate, Cholecalciferol Combination Tablet in Patients With Osteoporosis","status":"COMPLETED","sponsor":"Hanlim Pharm. Co., Ltd.","startDate":"2011-07-04","conditions":"Osteoporosis","enrollment":1053},{"nctId":"NCT01904110","phase":"PHASE4","title":"To Evaluate the Efficacy and the Safety of Monthly Versus Weekly Oral Risedronate With Vitamin D in Compliance, Improvement of Vitamin D and BMD in Korean Postmenopausal Osteoporotic Women","status":"COMPLETED","sponsor":"Hanlim Pharm. Co., Ltd.","startDate":"2012-12","conditions":"Osteoporosis","enrollment":196},{"nctId":"NCT01806792","phase":"PHASE3","title":"Post-menopausal Women Osteoporosis(Phase III)","status":"COMPLETED","sponsor":"Hanlim Pharm. Co., Ltd.","startDate":"2009-11","conditions":"Postmenopausal Women Osteoporosis","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["RisenexPlus tablet"],"phase":"marketed","status":"active","brandName":"Risedronate/Cholecalciferol combination","genericName":"Risedronate/Cholecalciferol combination","companyName":"Hanlim Pharm. Co., Ltd.","companyId":"hanlim-pharm-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Risedronate inhibits bone resorption by blocking osteoclast activity, while cholecalciferol (vitamin D3) enhances calcium absorption and supports bone mineralization. Used for Osteoporosis in postmenopausal women, Osteoporosis in men, Glucocorticoid-induced osteoporosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}