{"id":"ripazepam","rwe":[{"pmid":"9617631","year":"1998","title":"Mouse-specific carcinogens: an assessment of hazard and significance for validation of short-term carcinogenicity bioassays in transgenic mice.","finding":"","journal":"Human & experimental toxicology","studyType":"Clinical Study"},{"pmid":"9097123","year":"1996","title":"Ripazepam.","finding":"","journal":"IARC monographs on the evaluation of carcinogenic risks to humans","studyType":"Clinical Study"},{"pmid":"2985787","year":"1985","title":"Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in rat cerebral cortex.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"6724192","year":"1984","title":"Carcinogenicity studies in rodents and ripazepam, a minor tranquilizing agent.","finding":"","journal":"Fundamental and applied toxicology : official journal of the Society of Toxicology","studyType":"Clinical Study"},{"pmid":"996049","year":"1976","title":"Effects of diazepam and ripazepam on two measures of adjunctive drinking in rats.","finding":"","journal":"Pharmacology, biochemistry, and behavior","studyType":"Clinical Study"}],"tags":[{"label":"ripazepam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"pyrazapon","offLabel":[],"synonyms":["CI-683","CI 683","ripazepam","pyrazapon"],"timeline":[],"approvals":[],"brandName":"Pyrazapon","ecosystem":[],"mechanism":{"target":"GABA-A receptor; anion channel","modality":"Small Molecule","drugClass":"ripazepam","explanation":"Imagine your brain is like a busy city with many different neighborhoods. GABA receptors are like the traffic lights that help control the flow of information between these neighborhoods. Ripazepam is believed to affect how these traffic lights work, which can help calm down overactive brain activity.","oneSentence":"Ripazepam is thought to work by modulating the activity of GABA receptors in the brain.","technicalDetail":"Ripazepam is a benzodiazepine receptor agonist that acts on the GABA_A receptor, enhancing the effect of the neurotransmitter GABA and leading to sedative, hypnotic, and anxiolytic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2386","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=RIPAZEPAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:32:55.471811","biosimilars":[],"competitors":[{"drugName":"baclofen","drugSlug":"baclofen","fdaApproval":"1977-11-22","patentExpiry":"Sep 8, 2037","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"chlordiazepoxide","drugSlug":"chlordiazepoxide","fdaApproval":"1960-02-24","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"ciprofloxacin","drugSlug":"ciprofloxacin","fdaApproval":"1987-10-22","patentExpiry":"Nov 27, 2038","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"clonazepam","drugSlug":"clonazepam","fdaApproval":"1975-06-04","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"diazepam","drugSlug":"diazepam","fdaApproval":"1963-11-15","patentExpiry":"Oct 16, 2032","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"flumazenil","drugSlug":"flumazenil","fdaApproval":"1991-12-20","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"liothyronine","drugSlug":"liothyronine","fdaApproval":"1956-05-08","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"midazolam","drugSlug":"midazolam","fdaApproval":"1985-12-20","patentExpiry":"Jun 20, 2038","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"norfloxacin","drugSlug":"norfloxacin","fdaApproval":"1986-10-31","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"ofloxacin","drugSlug":"ofloxacin","fdaApproval":"1990-12-28","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"ripazepam","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"baclofen","brandName":"baclofen","genericName":"baclofen","approvalYear":"1977","relationship":"same-target"},{"drugId":"chlordiazepoxide","brandName":"chlordiazepoxide","genericName":"chlordiazepoxide","approvalYear":"1960","relationship":"same-target"},{"drugId":"ciprofloxacin","brandName":"ciprofloxacin","genericName":"ciprofloxacin","approvalYear":"1987","relationship":"same-target"},{"drugId":"clonazepam","brandName":"clonazepam","genericName":"clonazepam","approvalYear":"1975","relationship":"same-target"},{"drugId":"diazepam","brandName":"diazepam","genericName":"diazepam","approvalYear":"1963","relationship":"same-target"},{"drugId":"flumazenil","brandName":"flumazenil","genericName":"flumazenil","approvalYear":"1991","relationship":"same-target"},{"drugId":"liothyronine","brandName":"liothyronine","genericName":"liothyronine","approvalYear":"1956","relationship":"same-target"},{"drugId":"midazolam","brandName":"midazolam","genericName":"midazolam","approvalYear":"1985","relationship":"same-target"},{"drugId":"norfloxacin","brandName":"norfloxacin","genericName":"norfloxacin","approvalYear":"1986","relationship":"same-target"},{"drugId":"ofloxacin","brandName":"ofloxacin","genericName":"ofloxacin","approvalYear":"1990","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"92000WH9C9","CHEBI":"CHEBI:82529","INN_ID":"3751","UMLSCUI":"C0073389","ChEMBL_ID":"CHEMBL159298","KEGG_DRUG":"D05733","PUBCHEM_CID":"33474","MESH_SUPPLEMENTAL_RECORD_UI":"C009116"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"1998 Apr","pmid":"9617631","title":"Mouse-specific carcinogens: an assessment of hazard and significance for validation of short-term carcinogenicity bioassays in transgenic mice.","journal":"Human & experimental toxicology"},{"date":"1996","pmid":"9097123","title":"Ripazepam.","journal":"IARC monographs on the evaluation of carcinogenic risks to humans"},{"date":"1985 May","pmid":"2985787","title":"Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in rat cerebral cortex.","journal":"Journal of medicinal chemistry"},{"date":"1984 Apr","pmid":"6724192","title":"Carcinogenicity studies in rodents and ripazepam, a minor tranquilizing agent.","journal":"Fundamental and applied toxicology : official journal of the Society of Toxicology"},{"date":"1976 Aug","pmid":"996049","title":"Effects of diazepam and ripazepam on two measures of adjunctive drinking in rats.","journal":"Pharmacology, biochemistry, and behavior"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pyrazapon is a small molecule. It is also known by the synonyms CL-683 and Ripazepam.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}