{"id":"rioprostil","rwe":[],"tags":[{"label":"rioprostil","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Prostaglandin E2 receptor EP2 subtype","category":"target"},{"label":"PTGER2","category":"gene"},{"label":"Active","category":"status"},{"label":"Anti-Ulcer Agents","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"rostil","offLabel":[],"synonyms":["rioprostil","rostil","ORF15927","ORF-15927","RWJ15927","RWJ-15927"],"timeline":[],"approvals":[],"brandName":"Rostil","ecosystem":[],"mechanism":{"target":"Prostaglandin E2 receptor EP2 subtype","targets":[{"gene":"PTGER2","source":"DrugCentral","target":"Prostaglandin E2 receptor EP2 subtype","protein":"Prostaglandin E2 receptor EP2 subtype"}],"modality":"Small Molecule","drugClass":"rioprostil","explanation":"Think of prostaglandins like messengers that help different parts of the body communicate with each other. Prostaglandin E2 is one of these messengers that helps to reduce inflammation and pain. Rostil is like a key that unlocks the prostaglandin E2 receptor, allowing it to send these messages and help to reduce inflammation and pain.","oneSentence":"Rostil works by binding to the prostaglandin E2 receptor EP2 subtype, mimicking the action of prostaglandin E2 in the body.","technicalDetail":"Rostil acts as a prostaglandin E2 analogue by binding to the EP2 subtype of the prostaglandin E2 receptor, activating the receptor and triggering a downstream signaling cascade that ultimately leads to the reduction of inflammation and pain."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3529","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=RIOPROSTIL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:35:40.620848","biosimilars":[],"competitors":[{"drugName":"alprostadil","drugSlug":"alprostadil","fdaApproval":"1981-10-16","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"cloprostenol","drugSlug":"cloprostenol","fdaApproval":"","relationship":"same-target"},{"drugName":"dinoprost","drugSlug":"dinoprost","fdaApproval":"1976-05-18","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"dinoprostone","drugSlug":"dinoprostone","fdaApproval":"1977-08-23","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"iloprost","drugSlug":"iloprost","fdaApproval":"2004-12-29","patentExpiry":"Jul 18, 2044","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"indomethacin","drugSlug":"indomethacin","fdaApproval":"1965-06-10","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"mezlocillin","drugSlug":"mezlocillin","fdaApproval":"1981-09-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"misoprostol","drugSlug":"misoprostol","fdaApproval":"1988-12-27","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"omidenepag isopropyl","drugSlug":"omidenepag-isopropyl","fdaApproval":"2022-09-22","patentExpiry":"Oct 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"rofecoxib","drugSlug":"rofecoxib","fdaApproval":"1999-05-20","patentStatus":"Unknown","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"rioprostil","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"alprostadil","brandName":"alprostadil","genericName":"alprostadil","approvalYear":"1981","relationship":"same-target"},{"drugId":"cloprostenol","brandName":"cloprostenol","genericName":"cloprostenol","approvalYear":"","relationship":"same-target"},{"drugId":"dinoprost","brandName":"dinoprost","genericName":"dinoprost","approvalYear":"1976","relationship":"same-target"},{"drugId":"dinoprostone","brandName":"dinoprostone","genericName":"dinoprostone","approvalYear":"1977","relationship":"same-target"},{"drugId":"iloprost","brandName":"iloprost","genericName":"iloprost","approvalYear":"2004","relationship":"same-target"},{"drugId":"indomethacin","brandName":"indomethacin","genericName":"indomethacin","approvalYear":"1965","relationship":"same-target"},{"drugId":"mezlocillin","brandName":"mezlocillin","genericName":"mezlocillin","approvalYear":"1981","relationship":"same-target"},{"drugId":"misoprostol","brandName":"misoprostol","genericName":"misoprostol","approvalYear":"1988","relationship":"same-target"},{"drugId":"omidenepag-isopropyl","brandName":"omidenepag isopropyl","genericName":"omidenepag isopropyl","approvalYear":"2022","relationship":"same-target"},{"drugId":"rofecoxib","brandName":"rofecoxib","genericName":"rofecoxib","approvalYear":"1999","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"7JL402PVQR","CHEBI":"CHEBI:135498","INN_ID":"5299","UMLSCUI":"C0085199","ChEMBL_ID":"CHEMBL3301679","KEGG_DRUG":"D05732","PUBCHEM_CID":"5311413","MESH_DESCRIPTOR_UI":"D016630"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":100,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rostil is a small molecule with the synonyms BAY 06893, BAY-06893, ORF 15927, ORF-15927, RIOPROSTIL, and RIOPROSTIL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}