{"id":"riociguat-pill","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Dyspepsia"}]},"_chembl":{"chemblId":"CHEMBL2107834","moleculeType":"Small molecule","molecularWeight":"422.42"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Riociguat directly activates soluble guanylate cyclase (sGC), an enzyme that produces cyclic GMP, a key signaling molecule in vascular smooth muscle cells. By increasing cGMP levels, riociguat promotes smooth muscle relaxation and vasodilation in the pulmonary vasculature, reducing right ventricular afterload and improving hemodynamics in pulmonary hypertension.","oneSentence":"Riociguat is a soluble guanylate cyclase stimulator that increases cyclic GMP levels to promote vasodilation and reduce pulmonary vascular resistance.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:32:15.485Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pulmonary arterial hypertension (PAH)"},{"name":"Chronic thromboembolic pulmonary hypertension (CTEPH)"}]},"trialDetails":[{"nctId":"NCT04062565","phase":"PHASE3","title":"Trial to Evaluate Parenteral Treprostinil and Riociguat on Right Ventriculo-vascular Coupling and Morphology in Those With Advanced PAH","status":"RECRUITING","sponsor":"University of Arizona","startDate":"2019-03-25","conditions":"Pulmonary Arterial Hypertension","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Adempas"],"phase":"phase_3","status":"active","brandName":"Riociguat Pill","genericName":"Riociguat Pill","companyName":"University of Arizona","companyId":"university-of-arizona","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Riociguat is a soluble guanylate cyclase stimulator that increases cyclic GMP levels to promote vasodilation and reduce pulmonary vascular resistance. Used for Pulmonary arterial hypertension (PAH), Chronic thromboembolic pulmonary hypertension (CTEPH).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}