{"id":"ringer-lactato","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia (with renal impairment or massive transfusion)"},{"rate":null,"effect":"Hyperchloremic acidosis (with excessive administration)"},{"rate":null,"effect":"Pulmonary edema (with fluid overload)"},{"rate":null,"effect":"Hyponatremia (with excessive hypotonic fluid administration)"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lactated Ringer's is an intravenous crystalloid fluid containing sodium, potassium, calcium, chloride, and lactate in physiologic concentrations. The lactate is metabolized by the liver to bicarbonate, providing mild alkalinizing capacity. It restores intravascular volume and electrolyte balance, improving tissue perfusion and oxygen delivery in hypovolemic states.","oneSentence":"Lactated Ringer's solution replaces fluid and electrolytes lost through dehydration, hemorrhage, or burns by providing a balanced crystalloid solution that mimics plasma composition.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:05:07.091Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute dehydration and hypovolemia"},{"name":"Hemorrhagic shock and trauma resuscitation"},{"name":"Burn injury fluid replacement"},{"name":"Perioperative fluid maintenance and replacement"}]},"trialDetails":[{"nctId":"NCT06905834","phase":"PHASE2","title":"Evaluation of Allogenic Mesenchymal Stem Cell (MSC) Injection Therapy for Refractory Graft-versus-Host Disease (GVHD) Unresponsive to Conventional Treatments","status":"NOT_YET_RECRUITING","sponsor":"Instituto de Investigación Biomédica de Salamanca","startDate":"2026-05","conditions":"Dry Eye Disease (DED), Graft-Versus-Host Disease(GVHD)","enrollment":30},{"nctId":"NCT01619436","phase":"PHASE4","title":"The Effect of Clonidine in Glycemia During Coronary Artery Bypass Graft With Cardiopulmonary By-pass","status":"COMPLETED","sponsor":"Federal University of Juiz de Fora","startDate":"2011-01","conditions":"Glycemia During Coronary Artery Bypass Graft, Sedation During Pre-anesthetic Medication","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ringer lactato","genericName":"Ringer lactato","companyName":"Federal University of Juiz de Fora","companyId":"federal-university-of-juiz-de-fora","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lactated Ringer's solution replaces fluid and electrolytes lost through dehydration, hemorrhage, or burns by providing a balanced crystalloid solution that mimics plasma composition. Used for Acute dehydration and hypovolemia, Hemorrhagic shock and trauma resuscitation, Burn injury fluid replacement.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}