{"id":"ringer-lactate-rl","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Fluid overload / pulmonary edema"},{"rate":null,"effect":"Hyperchloremic acidosis (with large volumes)"},{"rate":null,"effect":"Hyponatremia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ringer lactate contains sodium, potassium, calcium, chloride, and lactate in physiologic concentrations that closely mimic plasma composition. It is administered intravenously to restore fluid balance in dehydration, hemorrhage, and surgical settings. The lactate component is metabolized by the liver to bicarbonate, providing mild alkalinizing effects and making it suitable for prolonged use.","oneSentence":"Ringer lactate is a crystalloid intravenous fluid that replaces lost body fluids and electrolytes to restore intravascular volume and maintain hemodynamic stability.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:05:11.841Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fluid resuscitation in hypovolemia and dehydration"},{"name":"Perioperative fluid replacement"},{"name":"Hemorrhagic shock management"},{"name":"Burn injury fluid replacement"}]},"trialDetails":[{"nctId":"NCT07239713","phase":"NA","title":"Clinical Effects of Ringers Lactate Versus Sterofundin/ Plasmalyte Solution in Patients With Sepsis","status":"RECRUITING","sponsor":"CMH Lahore Medical College and Institute of Dentistry","startDate":"2025-11-15","conditions":"Post Abdominal Surgery, Sepsis 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Ltd","startDate":"2002-03","conditions":"Low Cardiac Output","enrollment":230}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"SUBSTANCE-INDUCED PSYCHOTIC DISORDER"}],"_approvalHistory":[],"publicationCount":56,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hydration solution"],"phase":"marketed","status":"active","brandName":"Ringer lactate (RL)","genericName":"Ringer lactate (RL)","companyName":"Fundación Cardioinfantil Instituto de Cardiología","companyId":"fundaci-n-cardioinfantil-instituto-de-cardiolog-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ringer lactate (RL) is a small molecule solution used in medical settings, often in conjunction with other interventions such as sevoflurane or total intravenous anesthesia (TIVA). RL has been studied in various clinical trials for conditions including congenital heart defects, critical illness, and septic shock, among others.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}