{"id":"rilmazafone","rwe":[],"tags":[{"label":"rilmazafone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Insomnia","category":"indication"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Hypnotics and Sedatives","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":37.411,"date":"","count":16,"signal":"Hepatic function abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 16 times (LLR=37)"}],"commonSideEffects":[{"effect":"Hepatic function abnormal","drugRate":"LLR 37","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"rhythmy","offLabel":[],"synonyms":["450191-S","rilmazafone","rilmazafone hydrochloride","rilmazafone hydrochloride hydrate","rhythmy","rilmazafone HCl"],"timeline":[],"approvals":[],"brandName":"Rhythmy","ecosystem":[{"indication":"Insomnia","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"choline","slug":"choline","company":""},{"name":"daridorexant","slug":"daridorexant","company":"Idorsia Pharmaceuticals Ltd"},{"name":"diphenhydramine","slug":"diphenhydramine","company":"Mcneil Cons"}],"globalPrevalence":750000000}],"mechanism":{"modality":"Small Molecule","drugClass":"rilmazafone","explanation":"Imagine your brain is like a busy city, and GABA is like a calming traffic cop. RILMAZAFONE helps the traffic cop work more effectively, which can lead to a calming effect and help you fall asleep.","oneSentence":"RILMAZAFONE works by binding to the benzodiazepine receptor, enhancing the activity of the neurotransmitter GABA.","technicalDetail":"RILMAZAFONE acts as a partial agonist at the benzodiazepine receptor, specifically at the α1 subunit, which enhances the activity of GABA_A receptors, leading to an increase in chloride ion influx and a subsequent decrease in neuronal excitability."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2380","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=RILMAZAFONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:35:24.766869","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:40.472331+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"rilmazafone","indications":{"approved":[{"name":"Insomnia","source":"DrugCentral","snomedId":193462001,"regulator":"FDA","usPrevalence":70000000,"globalPrevalence":750000000,"prevalenceMethod":"curated","prevalenceSource":"Sleep Medicine Reviews, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"CU3H37T766","CHEBI":"CHEBI:135767","INN_ID":"5933","UMLSCUI":"C0073378","ChEMBL_ID":"CHEMBL2107197","KEGG_DRUG":"D01564","PUBCHEM_CID":"5069","SECONDARY_CAS_RN":"85815-37-8","MESH_SUPPLEMENTAL_RECORD_UI":"C041075"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":17,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rhythmy (RILMAZAFONE) is a small molecule drug in the rilmazafone class, used to treat insomnia. Its commercial status is unknown, and it is not clear if it is patented or available as a generic. The target of RILMAZAFONE is unknown, and it has been approved for use in treating insomnia. Further information on its pharmacokinetics and safety profile is not available. As a result, its use should be approached with caution.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:40.472331+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}