{"id":"rhuepo","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Hypertension"},{"rate":"10-20","effect":"Headache"},{"rate":"10-15","effect":"Arthralgias"},{"rate":"10-15","effect":"Fatigue"},{"rate":"5-10","effect":"Thrombotic events (stroke, MI, DVT)"},{"rate":"<1","effect":"Pure red cell aplasia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"rHuEPO is a recombinant version of the naturally occurring hormone erythropoietin (EPO), which regulates red blood cell production in the bone marrow. By activating the EPO receptor on erythroid progenitor cells, it promotes their proliferation and differentiation into mature red blood cells. This mechanism is used therapeutically to treat anemia by increasing hemoglobin and hematocrit levels.","oneSentence":"rHuEPO (recombinant human erythropoietin) stimulates erythropoiesis by binding to the erythropoietin receptor on bone marrow progenitor cells to increase red blood cell production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:04:55.862Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anemia associated with chronic kidney disease"},{"name":"Anemia in patients with cancer receiving chemotherapy"},{"name":"Anemia in HIV-infected patients receiving zidovudine therapy"},{"name":"Perioperative anemia in patients undergoing elective surgery"}]},"trialDetails":[{"nctId":"NCT07045155","phase":"PHASE4","title":"Pegmolesatide Treatment for Anemia in Patients Undergoing Long-term Dialysis","status":"RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2025-08-01","conditions":"Dialysis; Complications, Chronic Kidney 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INFECTION"}],"_approvalHistory":[],"publicationCount":2399,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["rHuEPO group","Recombinant Human Erythropoietin Injection"],"phase":"marketed","status":"active","brandName":"rHuEPO","genericName":"rHuEPO","companyName":"Amgen","companyId":"amgen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"rHuEPO (recombinant human erythropoietin) stimulates erythropoiesis by binding to the erythropoietin receptor on bone marrow progenitor cells to increase red blood cell production. Used for Anemia associated with chronic kidney disease, Anemia in patients with cancer receiving chemotherapy, Anemia in HIV-infected patients receiving zidovudine therapy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}