{"id":"rhpro-uk-simulation-agent","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding / hemorrhage"},{"rate":null,"effect":"Intracranial hemorrhage"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Prourokinase (pro-UK) is a serine protease precursor that acts as a fibrinolytic agent. When administered, it is converted to its active form (urokinase) which then activates plasminogen to plasmin, leading to degradation of fibrin in thrombi. This mechanism makes it useful for thrombolytic therapy in acute thrombotic conditions.","oneSentence":"rhPro-UK is a recombinant human prourokinase that converts plasminogen to plasmin to dissolve blood clots.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:31:58.717Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute ischemic stroke"},{"name":"Acute myocardial infarction"},{"name":"Pulmonary embolism"}]},"trialDetails":[{"nctId":"NCT03578822","phase":"PHASE3","title":"Thrombolysis With rhPro-UK in 4.5-6 Hours After Acute Ischemic Stroke in a Double-blinded,Controlled Trial","status":"COMPLETED","sponsor":"Tasly Biopharmaceuticals Co., Ltd.","startDate":"2018-08-10","conditions":"Acute Ischaemic Stroke","enrollment":149}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"rhPro-UK simulation agent","genericName":"rhPro-UK simulation agent","companyName":"Tasly Biopharmaceuticals Co., Ltd.","companyId":"tasly-biopharmaceuticals-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"rhPro-UK is a recombinant human prourokinase that converts plasminogen to plasmin to dissolve blood clots. Used for Acute ischemic stroke, Acute myocardial infarction, Pulmonary embolism.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}