{"id":"rhfsh","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Abdominal pain/bloating"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL5315064","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"rhFSH is a recombinant form of the naturally occurring pituitary hormone follicle-stimulating hormone. It acts on FSH receptors in the ovary to promote follicular development and estrogen production, essential for ovulation. This mechanism is used therapeutically to induce controlled ovarian hyperstimulation in assisted reproductive technologies.","oneSentence":"rhFSH (recombinant human follicle-stimulating hormone) stimulates the growth and maturation of ovarian follicles in women by binding to FSH receptors on granulosa cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:04:52.101Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infertility in women undergoing assisted reproductive technology (ART)"},{"name":"Anovulation and ovulatory disorders in women"}]},"trialDetails":[{"nctId":"NCT06414096","phase":"PHASE1","title":"Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome","status":"RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2024-10-01","conditions":"Infertility, Obesity","enrollment":5},{"nctId":"NCT04719000","phase":"PHASE4","title":"PErsonalized Addition of Recombinant LH in Ovarian Stimulation","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2021-02-04","conditions":"Infertility","enrollment":120},{"nctId":"NCT03506243","phase":"PHASE3","title":"Randomized Controlled Study of Comparing Follitrope Versus Gonal-f in Chinese Infertility Women.","status":"COMPLETED","sponsor":"Hangzhou YuYuan Bioscience Technology Co., Ltd.","startDate":"2015-04","conditions":"Infertility, Female","enrollment":451},{"nctId":"NCT02047227","phase":"PHASE3","title":"Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART)","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2014-01-31","conditions":"Infertility","enrollment":939},{"nctId":"NCT03071172","phase":"PHASE3","title":"Clinical Study of Recombinant Human Follitropin for Injection Assisted in COH Assisted IVF-ET","status":"UNKNOWN","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2017-03","conditions":"Ovarian Hyperstimulation Syndrome","enrollment":252},{"nctId":"NCT02329483","phase":"","title":"Monitoring the Early Follicular Phase With Androstenedione in Low-dose Step-up Ovulation Induction in High Responders","status":"UNKNOWN","sponsor":"Bagcilar Training and Research Hospital","startDate":"2014-12","conditions":"Infertility, Ovarian Hyperstimulation Syndrome","enrollment":50},{"nctId":"NCT01029470","phase":"PHASE2","title":"To Describe the Effect of rhLH Supplementation in Women With Hyporesponse to rhFSH After Pituitary Downregulation","status":"UNKNOWN","sponsor":"Peking University Third Hospital","startDate":"2009-12","conditions":"Infertility","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":360,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"rhFSH","genericName":"rhFSH","companyName":"Fundación Santiago Dexeus Font","companyId":"fundaci-n-santiago-dexeus-font","modality":"Small molecule","firstApprovalDate":"","aiSummary":"rhFSH (recombinant human follicle-stimulating hormone) stimulates the growth and maturation of ovarian follicles in women by binding to FSH receptors on granulosa cells. Used for Infertility in women undergoing assisted reproductive technology (ART), Anovulation and ovulatory disorders in women.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}