{"id":"rhegf","safety":{"commonSideEffects":[{"rate":null,"effect":"Local tissue irritation"},{"rate":null,"effect":"Infection at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"RhEGF binds to epidermal growth factor receptors on epithelial and fibroblast cells, stimulating proliferation, migration, and differentiation to accelerate tissue repair. This mechanism is particularly applied in dental and periodontal regeneration, where it enhances bone and soft tissue healing following surgical or pathological defects.","oneSentence":"RhEGF is a recombinant human epidermal growth factor that promotes tissue regeneration and wound healing in oral and dental tissues.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:31:59.194Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Periodontal bone defects and regeneration"},{"name":"Oral and dental tissue healing following surgical procedures"}]},"trialDetails":[{"nctId":"NCT04298606","phase":"EARLY_PHASE1","title":"A Vaccine (CIMAvax-EGF) for the Prevention of Lung Cancer Development or Recurrence","status":"COMPLETED","sponsor":"Roswell Park Cancer Institute","startDate":"2021-11-22","conditions":"Chronic Obstructive Pulmonary Disease, Lung Non-Small Cell Carcinoma, Pneumonia","enrollment":20},{"nctId":"NCT06011772","phase":"EARLY_PHASE1","title":"EGF-Depleting Therapy CIMAvax-EGF in Combination With Standard Therapy for RAS- and BRAF Wild-Type Metastatic Colorectal Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Roswell Park Cancer Institute","startDate":"2023-12-18","conditions":"Colo-rectal Cancer","enrollment":2},{"nctId":"NCT02955290","phase":"PHASE1, PHASE2","title":"CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Roswell Park Cancer Institute","startDate":"2016-12-22","conditions":"Advanced Head and Neck Squamous Cell Carcinoma, Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma","enrollment":51},{"nctId":"NCT07078851","phase":"NA","title":"Comparing the Efficacy and Safety of Fractional Picosecond Laser and Gold Microneedle in the Treatment of Acne Scars","status":"COMPLETED","sponsor":"First Affiliated Hospital of Chongqing Medical University","startDate":"2023-09-01","conditions":"Acne Scarring, Acne Scars","enrollment":20},{"nctId":"NCT02554851","phase":"PHASE3","title":"Efficacy and Safety Evaluation of the Intralesional Recombinant Human Epidermal Growth Factor (rhEGF) in Subjects With Diabetic Foot Ulcer.","status":"UNKNOWN","sponsor":"The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)","startDate":"2017-01","conditions":"Foot Ulcer, Diabetic, Epidermal Growth Factor","enrollment":304},{"nctId":"NCT05335720","phase":"NA","title":"Efficacy and Safety Evaluation of EASYEF® in Acute Wound (Split-thickness Skin Graft Donor Site)","status":"COMPLETED","sponsor":"PT. Daewoong Infion","startDate":"2019-07-19","conditions":"Skin Graft Scar, Split-Thickness Skin Graft (STSG)","enrollment":10},{"nctId":"NCT05228093","phase":"NA","title":"A Randomized Controlled Clinical Trial of Surgery Versus Conservative Treatment for Mild and Moderate-grade Nasopharyngeal Necrosis","status":"UNKNOWN","sponsor":"Sun Yat-sen University","startDate":"2021-11-01","conditions":"Nasopharyngeal Carcinoma, Postradiation, Necrosis, Endoscopy Surgery, Conservative Treatment","enrollment":216},{"nctId":"NCT05219461","phase":"PHASE1","title":"Pharmacokinetics, Safety, and Tolerability of rhEGF Eye Drops in Healthy Male Subjects","status":"COMPLETED","sponsor":"Daewoong Bio Inc.","startDate":"2019-03-29","conditions":"Dry Eye Syndromes","enrollment":48},{"nctId":"NCT04995354","phase":"PHASE2, PHASE3","title":"Efficacy of EGF-loaded Self Healing Gel in Treatment of Oral Mucositis","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2022-06-01","conditions":"Oral Mucositis","enrollment":90},{"nctId":"NCT04375618","phase":"PHASE1","title":"RhEGF Incorporated in An Absorbable Collagen Membrane for The Management Of Gingival Recession Defects","status":"UNKNOWN","sponsor":"SVS Institute of Dental Sciences","startDate":"2019-10-01","conditions":"Periodontitis","enrollment":30},{"nctId":"NCT04211597","phase":"NA","title":"EGF-loaded Chitosan to Facilitate Healing and Prevent Scar Formation of Cesarean Wound","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2017-09-05","conditions":"Cesarean Wound, Scar; Previous Cesarean Section, Complicating Pregnancy or Childbirth, Affecting Fetus or Newborn","enrollment":60},{"nctId":"NCT03051880","phase":"NA","title":"Preventive Effect of EGF Cream for Cutaneous Adverse Event of EGFR Inhibitors","status":"UNKNOWN","sponsor":"The Catholic University of Korea","startDate":"2016-11","conditions":"Drug-Related Side Effects and Adverse Reactions, Epidermal Growth Factor","enrollment":40},{"nctId":"NCT03047863","phase":"NA","title":"Therapeutic Effect of EGF Cream for Cutaneous Adverse Event of EGFR Inhibitors","status":"UNKNOWN","sponsor":"The Catholic University of Korea","startDate":"2016-11","conditions":"Drug-Related Side Effects and Adverse Reactions, Epidermal Growth Factor","enrollment":20},{"nctId":"NCT02303197","phase":"PHASE3","title":"Clinical Trial on the Efficacy and Safety of Chining Decoction in the Treatment of Radiation Stomatitis","status":"COMPLETED","sponsor":"Tianjin Medical University Cancer Institute and Hospital","startDate":"2014-05","conditions":"Head and Neck Cancer","enrollment":70},{"nctId":"NCT00845819","phase":"PHASE2","title":"Study of Epidermal Growth Factor on Oral Mucositis Induced by Intensive Chemotherapy for Hematologic Malignancies","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2009-02","conditions":"Oral Mucositis","enrollment":138},{"nctId":"NCT01099891","phase":"PHASE3","title":"The Clinical Study for Evaluation of Efficacy and Safety of EGF on Oral Mucositis in Radiation Therapy Patients","status":"UNKNOWN","sponsor":"Daewoong Pharmaceutical Co. LTD.","startDate":"2010-03","conditions":"Stomatitis","enrollment":300},{"nctId":"NCT01629199","phase":"PHASE3","title":"Efficacy and Safety of rhEGF in Diabetic Foot Ulcer Patients With Uncontrolled Diabetic Mellitus","status":"COMPLETED","sponsor":"Daewoong Pharmaceutical Co. LTD.","startDate":"2010-10","conditions":"Diabetic Foot Ulcer Patients With Uncontrolled Diabetes Mellitus","enrollment":176},{"nctId":"NCT00516685","phase":"PHASE2, PHASE3","title":"Vaccine Therapy in Treating Patients With Non-Small Cell Lung Cancer (NSCLC) Stages IIIB/IV","status":"TERMINATED","sponsor":"Bioven Sdn. Bhd.","startDate":"2007-07","conditions":"Non-small-cell Lung Cancer (NSCLC) Stage IIIb/IV","enrollment":230}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["EGF+Collagen","EASYEF®"],"phase":"phase_3","status":"active","brandName":"RhEGF","genericName":"RhEGF","companyName":"SVS Institute of Dental Sciences","companyId":"svs-institute-of-dental-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"RhEGF is a recombinant human epidermal growth factor that promotes tissue regeneration and wound healing in oral and dental tissues. Used for Periodontal bone defects and regeneration, Oral and dental tissue healing following surgical procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}