{"id":"rhdnase","safety":{"commonSideEffects":[{"rate":null,"effect":"Voice hoarseness"},{"rate":null,"effect":"Pharyngitis"},{"rate":null,"effect":"Laryngitis"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Chest pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"In cystic fibrosis and other conditions with thick airway secretions, neutrophil death releases large amounts of DNA that increases sputum viscosity and impairs clearance. rhDNAse cleaves this extracellular DNA, reducing mucus thickness and improving airway function. 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