{"id":"rhbnp","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Renal dysfunction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"BNP is a cardiac hormone normally released by the ventricles in response to stretch and increased pressure. rhBNP binds to natriuretic peptide receptors on vascular smooth muscle and other tissues, activating guanylate cyclase and increasing cGMP levels. This leads to vasodilation, reduced sodium reabsorption in the kidneys, decreased sympathetic tone, and improved cardiac output, making it useful in acute heart failure management.","oneSentence":"rhBNP (recombinant human B-type natriuretic peptide) mimics the body's natural natriuretic peptide to promote vasodilation, reduce cardiac preload and afterload, and improve hemodynamics in acute decompensated heart failure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:05:01.900Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute decompensated heart failure"}]},"trialDetails":[{"nctId":"NCT07086287","phase":"NA","title":"Evaluation of the Efficacy of rhBNP in Patients With Diuretic Resistance After Cardiac Surgery","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital of Anhui Medical University","startDate":"2025-08-01","conditions":"After Cardiac Surgery, Diuretic Resistance","enrollment":120},{"nctId":"NCT05716984","phase":"PHASE4","title":"rhBNP in Type 3 Pulmonary Hypertension","status":"UNKNOWN","sponsor":"Shengjing Hospital","startDate":"2023-04-15","conditions":"Group 3 Pulmonary Hypertension","enrollment":72},{"nctId":"NCT04033861","phase":"PHASE4","title":"Early rhBNP on Myocardial Remodeling and Reperfusion in Patients With STEMI","status":"UNKNOWN","sponsor":"RenJi Hospital","startDate":"2019-06-19","conditions":"ST Segment Elevated Myocardial Infarction","enrollment":352},{"nctId":"NCT05723315","phase":"NA","title":"Effect of rhBNP on CMD in Patients With STEMI After PPCI","status":"UNKNOWN","sponsor":"Henan Institute of Cardiovascular Epidemiology","startDate":"2023-02-20","conditions":"STEMI","enrollment":160},{"nctId":"NCT05111769","phase":"NA","title":"Preliminary Study on the Clinical Effect of Recombinant Human Brain Natriuretic Peptide on Sepsis Complicated With Heart Failure","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2021-12-01","conditions":"Sepsis","enrollment":70},{"nctId":"NCT01941576","phase":"NA","title":"Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2013-09-01","conditions":"Congenital Heart Defects, Tetralogy Of Fallot","enrollment":120},{"nctId":"NCT04157868","phase":"PHASE4","title":"Early rhBNP on Myocardial Work in Patients With STEMI","status":"UNKNOWN","sponsor":"RenJi Hospital","startDate":"2019-11-30","conditions":"ST-Segment Elevated Myocardial Infarction","enrollment":200},{"nctId":"NCT02742909","phase":"PHASE4","title":"Acute Effects of rhBNP in Patients With PH Associated With Acute Exacerbation of Chronic Pulmonary Disease","status":"COMPLETED","sponsor":"LI ZHAO","startDate":"2015-12","conditions":"Pulmonary Hypertension","enrollment":9},{"nctId":"NCT01837849","phase":"","title":"A Comparison of Recombinant Human Brain Natriuretic Peptide and Dobutamine","status":"COMPLETED","sponsor":"Nantong University","startDate":"2011-01","conditions":"Acute Decompensated Heart Failure","enrollment":104},{"nctId":"NCT01625403","phase":"PHASE2","title":"Recombinant BNP on Heart and Renal Function in Acute Heart Failure","status":"UNKNOWN","sponsor":"Shanghai Chest Hospital","startDate":"2012-07","conditions":"Acute Heart Failure, Acute Renal Failure","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":95,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Recombinant Human Brain Natriuretic Peptide"],"phase":"marketed","status":"active","brandName":"rhBNP","genericName":"rhBNP","companyName":"LI ZHAO","companyId":"li-zhao","modality":"Small molecule","firstApprovalDate":"","aiSummary":"rhBNP (recombinant human B-type natriuretic peptide) mimics the body's natural natriuretic peptide to promote vasodilation, reduce cardiac preload and afterload, and improve hemodynamics in acute decompensated heart failure. Used for Acute decompensated heart failure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}