{"id":"retin-a-micro-microsphere-0-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Peeling/desquamation"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Burning/stinging"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL38","moleculeType":"Small molecule","molecularWeight":"300.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tretinoin is a retinoid that binds to nuclear retinoid receptors, promoting keratinocyte differentiation and increased cell turnover. The microsphere formulation provides controlled release of tretinoin into the skin, reducing irritation while improving acne lesions and photoaged skin. It works by decreasing cohesiveness of follicular epithelial cells and increasing skin cell renewal.","oneSentence":"Retin-A Micro delivers tretinoin (a vitamin A derivative) in microsphere form to normalize skin cell turnover and reduce comedone formation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:37:07.487Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"},{"name":"Photoaged skin (fine wrinkles, mottled hyperpigmentation, roughness)"}]},"trialDetails":[{"nctId":"NCT01522456","phase":"PHASE4","title":"Split-face Tolerability Comparison Between Adapalene-Benzoyl Peroxide Gel Versus Tretinoin Gel","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2012-04","conditions":"Acne Vulgaris","enrollment":73},{"nctId":"NCT04883736","phase":"EARLY_PHASE1","title":"A Study Comparing Tretinoin Gel Microsphere, 0.1% and RETIN-A MICRO ® Gel Microsphere, 0.1% in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2020-08-31","conditions":"Acne Vulgaris","enrollment":973},{"nctId":"NCT01135069","phase":"PHASE3","title":"Bioequivalence Study of Generic Tretinoin 0.1% Microsphere Gel, 0.1% Retin-A Micro® and Placebo","status":"COMPLETED","sponsor":"Spear Pharmaceuticals","startDate":"2009-10","conditions":"Acne","enrollment":480}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Retin-A Micro Microsphere 0.1%","genericName":"Retin-A Micro Microsphere 0.1%","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Retin-A Micro delivers tretinoin (a vitamin A derivative) in microsphere form to normalize skin cell turnover and reduce comedone formation. Used for Acne vulgaris, Photoaged skin (fine wrinkles, mottled hyperpigmentation, roughness).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}