{"id":"resveratrol-pill","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Resveratrol is a natural polyphenol found in grapes and red wine that acts as a sirtuin activator, particularly SIRT1, which regulates cellular metabolism and stress responses. It also functions as an antioxidant and anti-inflammatory agent by scavenging free radicals and modulating NF-κB signaling. These mechanisms are proposed to support cardiovascular health, metabolic function, and cellular longevity.","oneSentence":"Resveratrol is a polyphenolic compound that activates sirtuins and other cellular stress-response pathways to promote antioxidant and anti-inflammatory effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:04:52.851Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cardiovascular health support"},{"name":"Metabolic and anti-aging applications"}]},"trialDetails":[{"nctId":"NCT06585865","phase":"NA","title":"Strength Training and Resveratrol","status":"RECRUITING","sponsor":"Texas Tech University","startDate":"2025-06-13","conditions":"Sarcopenia, Anabolic Resistance","enrollment":36},{"nctId":"NCT03743636","phase":"PHASE3","title":"Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2018-10-01","conditions":"Peripheral Artery Disease","enrollment":90},{"nctId":"NCT03597568","phase":"NA","title":"Resveratrol and Vascular Function in CKD","status":"COMPLETED","sponsor":"Diana Jalal","startDate":"2019-01-01","conditions":"Chronic Kidney Diseases, Endothelial Dysfunction","enrollment":25},{"nctId":"NCT01321151","phase":"PHASE1, PHASE2","title":"Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2011-03","conditions":"Sports Concussion","enrollment":12},{"nctId":"NCT03384329","phase":"PHASE4","title":"Efficacy of Resveratrol in Depression","status":"COMPLETED","sponsor":"Russian Academy of Medical Sciences","startDate":"2018-07-04","conditions":"Depression","enrollment":30},{"nctId":"NCT01782911","phase":"NA","title":"Effect of Resveratrol on Metabolic Parameters and Oocyte Quality in PCOS Patients","status":"COMPLETED","sponsor":"IVI Madrid","startDate":"2013-02-01","conditions":"Androgen Profile, Inflammatory Markers, IVF Outcome","enrollment":10},{"nctId":"NCT02565979","phase":"NA","title":"Long-term Resveratrol and Metabolism","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2016-04","conditions":"Pre-diabetes","enrollment":42},{"nctId":"NCT02909699","phase":"","title":"Cardiovascular Health of Older Adults and Resveratrol (CORE)","status":"COMPLETED","sponsor":"University of Florida","startDate":"2016-11","conditions":"Aging","enrollment":27},{"nctId":"NCT02129595","phase":"NA","title":"Resveratrol and First-degree Relatives of Type 2 Diabetic Patients","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2014-04","conditions":"Pre-diabetes","enrollment":15},{"nctId":"NCT02261844","phase":"PHASE1, PHASE2","title":"Resveratrol and Human Hepatocyte Function in Cancer","status":"WITHDRAWN","sponsor":"University of Louisville","startDate":"2015-12","conditions":"Liver Cancer","enrollment":""},{"nctId":"NCT02475564","phase":"PHASE4","title":"Resveratrol for Pain Due to Endometriosis","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2015-06","conditions":"Endometriosis","enrollment":44},{"nctId":"NCT01668836","phase":"NA","title":"Influence of Caloric Restriction and Resveratrol in the Sirtuin System in Women and Men Aged 55 to 65 Years","status":"COMPLETED","sponsor":"InCor Heart Institute","startDate":"2012-08","conditions":"Vascular System Injuries, Lipid Metabolism Disorders, Endothelial Disfunction","enrollment":48},{"nctId":"NCT01766180","phase":"NA","title":"Cerebrovascular and Cognitive Improvement by Resveratrol (resVida) and Fruitflow-II (CCIRF-II)","status":"UNKNOWN","sponsor":"Neurolgy Institute for Brain Health and Fitness","startDate":"2013-01","conditions":"Memory Impairment","enrollment":80},{"nctId":"NCT02247596","phase":"PHASE2","title":"Effects of High-Dose Resveratrol in Non-Diabetic Obese Males","status":"COMPLETED","sponsor":"Khoo Teck Puat Hospital","startDate":"2009-07","conditions":"Obesity, Diabetes","enrollment":36},{"nctId":"NCT01638780","phase":"NA","title":"Resveratrol and Type 2 Diabetes","status":"UNKNOWN","sponsor":"Maastricht University Medical Center","startDate":"2012-05","conditions":"Type 2 Diabetes","enrollment":24},{"nctId":"NCT00823381","phase":"NA","title":"Effect of Resvida, a Comparison With Calorie Restriction Regimen","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2009-01","conditions":"Obesity, Metabolic Syndrome, Diabetes","enrollment":58},{"nctId":"NCT01593605","phase":"NA","title":"Resveratrol-Leucine Metabolite Synergy in Pre-diabetes","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2012-02","conditions":"Impaired Glucose Tolerance","enrollment":36},{"nctId":"NCT01244360","phase":"NA","title":"The Effects of Resveratrol Supplementation on Measurements of Health and Human Performance","status":"UNKNOWN","sponsor":"Marywood University","startDate":"2010-11","conditions":"Inflammation","enrollment":44},{"nctId":"NCT00998504","phase":"NA","title":"resVida and Fat Oxidation","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2009-10","conditions":"Obesity","enrollment":18}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Resveratrol Pill","genericName":"Resveratrol Pill","companyName":"Russian Academy of Medical Sciences","companyId":"russian-academy-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Resveratrol is a small molecule with the chemical name 3,5,4'-Trihydroxy-trans-stilbene, used in clinical trials to study various conditions including pre-diabetes, vascular system injuries, lipid metabolism disorders, endothelial dysfunction, and liver cancer. Clinical trials have investigated the effects of resveratrol on insulin sensitivity, brown adipose tissue, and metabolic profile in first-degree relatives of type 2 diabetic patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}