{"id":"resveratrol-nasal-spray","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Gastrointestinal effects (if systemic absorption)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Resveratrol is a natural polyphenol found in grapes and other plants that acts as an antioxidant and anti-inflammatory agent. It activates sirtuin proteins (particularly SIRT1) and other cellular signaling pathways involved in stress resistance and longevity. When delivered intranasally, it may provide direct access to nasal and potentially systemic tissues to modulate inflammatory and oxidative processes.","oneSentence":"Resveratrol is a polyphenolic antioxidant that activates sirtuins and other cellular pathways to reduce inflammation and oxidative stress.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:31:57.215Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neurodegenerative disease or cognitive decline (investigational)"},{"name":"Inflammatory or oxidative stress-related nasal/respiratory conditions (investigational)"}]},"trialDetails":[{"nctId":"NCT05684848","phase":"NA","title":"Evaluate the Effect of Nasal Spray in the Prevention of RTI in Children With Pre-school Wheezing","status":"UNKNOWN","sponsor":"Noos S.r.l.","startDate":"2022-11-01","conditions":"Wheezing, Recurrent Respiratory Tract Infections","enrollment":252},{"nctId":"NCT03349619","phase":"PHASE4","title":"Nebulized Resveratrol Plus Carboxymethyl-β-Glucan for Reducing IL-5 in Children With Allergic Rhinitis","status":"COMPLETED","sponsor":"Istituto per la Ricerca e l'Innovazione Biomedica","startDate":"2018-03-05","conditions":"Allergic Rhinitis","enrollment":88},{"nctId":"NCT02130440","phase":"PHASE3","title":"Evaluation of the Beneficial Effects of a Nasal Spray of Resveratrol in Children With Seasonal Allergic Rhinitis","status":"COMPLETED","sponsor":"University of Campania Luigi Vanvitelli","startDate":"2012-11","conditions":"Seasonal Allergic Rhinitis","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Resveratrol nasal spray","genericName":"Resveratrol nasal spray","companyName":"University of Campania Luigi Vanvitelli","companyId":"university-of-campania-luigi-vanvitelli","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Resveratrol is a polyphenolic antioxidant that activates sirtuins and other cellular pathways to reduce inflammation and oxidative stress. Used for Neurodegenerative disease or cognitive decline (investigational), Inflammatory or oxidative stress-related nasal/respiratory conditions (investigational).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}