{"id":"resveratrol-based-mouthwash","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral irritation or staining"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Taste alteration"}]},"_chembl":{"chemblId":"CHEMBL165","moleculeType":"Small molecule","molecularWeight":"228.25"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Resveratrol is a polyphenolic compound that acts as a free radical scavenger and activates sirtuins and other cellular pathways involved in stress resistance. When formulated as a mouthwash, it targets oral tissues to reduce oxidative stress and inflammation, potentially improving gum health and reducing periodontal disease progression. The compound may also have antimicrobial properties that contribute to oral health benefits.","oneSentence":"Resveratrol exerts antioxidant and anti-inflammatory effects in the oral cavity by scavenging reactive oxygen species and modulating inflammatory pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:31:52.304Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Periodontal disease / gingivitis (Phase 3)"},{"name":"Oral inflammation and plaque reduction"}]},"trialDetails":[{"nctId":"NCT07393802","phase":"PHASE3","title":"Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth","status":"NOT_YET_RECRUITING","sponsor":"University of Baghdad","startDate":"2026-03","conditions":"Mouthwash, Chlorhexidine, Biofilm Formation","enrollment":20},{"nctId":"NCT06711263","phase":"NA","title":"Role of Herbal Based Mouthwashes in Plaque Control","status":"NOT_YET_RECRUITING","sponsor":"Ajman University","startDate":"2024-12-20","conditions":"Plaque Induced Gingival Disease","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Resveratrol-Based Mouthwash","genericName":"Resveratrol-Based Mouthwash","companyName":"University of Baghdad","companyId":"university-of-baghdad","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Resveratrol exerts antioxidant and anti-inflammatory effects in the oral cavity by scavenging reactive oxygen species and modulating inflammatory pathways. Used for Periodontal disease / gingivitis (Phase 3), Oral inflammation and plaque reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}