{"id":"restalyne-silk","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site swelling"},{"rate":null,"effect":"Injection site bruising"},{"rate":null,"effect":"Injection site redness"},{"rate":null,"effect":"Injection site tenderness"},{"rate":null,"effect":"Lip asymmetry"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Restylane Silk uses stabilized hyaluronic acid (a naturally occurring polysaccharide) to restore lost volume and enhance lip fullness and definition. The filler particles are smaller than standard Restylane, allowing for smoother integration into the dermis and a more natural appearance. It provides both immediate volumization and subtle contouring of the lips and surrounding perioral region.","oneSentence":"Restylane Silk is a hyaluronic acid-based dermal filler that adds volume and smoothness to the lips and perioral area by integrating into the dermis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:04:53.073Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Lip augmentation and enhancement"},{"name":"Perioral lines and wrinkles"}]},"trialDetails":[{"nctId":"NCT02818556","phase":"PHASE4","title":"A Clinical Study Comparing Restylane® Silk and Belotero Balance® for the Treatment of Superficial, Vertical Perioral Lines","status":"UNKNOWN","sponsor":"The Maas Clinic","startDate":"2016-06","conditions":"Perioral Rhytids","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Restalyne Silk","genericName":"Restalyne Silk","companyName":"The Maas Clinic","companyId":"the-maas-clinic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Restalyne Silk is a protein-based dermal filler used to treat superficial, vertical perioral lines. It is a type of silk fibroin, a protein modality, and has been studied in clinical trials for the treatment of perioral rhytids.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}