{"id":"reserpiline","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Hypertensive disorder","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"reserpilin","offLabel":[],"synonyms":["reserpiline hydrochloride","reserpiline","(-)-Reserpiline","elliptamine","reserpilin","reserpiline HCl"],"timeline":[],"approvals":[],"brandName":"Reserpilin","ecosystem":[{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your brain's 'fight or flight' response is like a fire alarm that gets triggered when you're stressed or excited. Reserpine essentially silences this alarm by removing the chemicals that make it go off, which can help lower blood pressure and reduce anxiety.","oneSentence":"Reserpine works by depleting catecholamines and serotonin in the brain, leading to a decrease in sympathetic nervous system activity.","technicalDetail":"Reserpine acts as a vesicular monoamine transporter 2 (VMAT2) inhibitor, preventing the storage and release of catecholamines (dopamine, norepinephrine, and epinephrine) and serotonin in presynaptic neurons, thereby reducing their availability for neurotransmission."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3522","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=reserpiline","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:34:21.845953","biosimilars":[],"competitors":[],"genericName":"reserpiline","indications":{"approved":[{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"C0N6EP99UK","CHEBI":"CHEBI:135667","PUBCHEM_CID":"67228","SECONDARY_CAS_RN":"63647-55-2"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Reserpine is a small molecule medication with the synonyms including Reserpilic acid dimethylaminoethyl ester dihydrochloride. It is also known by other names such as Paratensiol and Resporisan.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}