{"id":"rescue-medication-self-injectable-epinephrine","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Hypertension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Epinephrine acts as a non-selective adrenergic agonist, stimulating alpha-1 receptors to cause vasoconstriction and increase blood pressure, and beta-2 receptors to promote bronchodilation and reduce airway edema. It also stabilizes mast cells and basophils, reducing further release of inflammatory mediators such as histamine and leukotrienes that drive anaphylactic reactions.","oneSentence":"Epinephrine is a sympathomimetic amine that binds to alpha and beta adrenergic receptors to rapidly reverse the symptoms of anaphylaxis by increasing blood pressure, improving airway patency, and reducing allergic mediator release.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:52:25.019Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anaphylaxis (emergency rescue treatment)"},{"name":"Severe allergic reactions"}]},"trialDetails":[{"nctId":"NCT02478398","phase":"PHASE3","title":"Efficacy and Safety Study of RAGWITEK™ (MK-3641) in Children With Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (MK-3641-008)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2015-07-20","conditions":"Rhinitis, Allergic, Seasonal","enrollment":1025},{"nctId":"NCT01700192","phase":"PHASE3","title":"Efficacy and Safety Study of SCH 900237/MK-8237 in Children and Adults With House Dust Mite-Induced Allergic Rhinitis/Rhinoconjunctivitis (P05607)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2013-01","conditions":"Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Nonseasonal","enrollment":1482},{"nctId":"NCT02256553","phase":"PHASE4","title":"Safety Study of MK-3641 and MK-7243 Co-administered in Adult Participants With Ragweed and Grass Pollen Induced Allergic Rhinitis (P08607, MK-3641-006)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2014-10","conditions":"Rhinitis, Allergic, Seasonal","enrollment":102}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Rescue Medication: Self-Injectable Epinephrine","genericName":"Rescue Medication: Self-Injectable Epinephrine","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epinephrine is a sympathomimetic amine that binds to alpha and beta adrenergic receptors to rapidly reverse the symptoms of anaphylaxis by increasing blood pressure, improving airway patency, and reducing allergic mediator release. Used for Anaphylaxis (emergency rescue treatment), Severe allergic reactions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}