{"id":"rescue-intravitreal-aflibercept-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Conjunctival hemorrhage"},{"rate":null,"effect":"Eye pain"},{"rate":null,"effect":"Floaters"},{"rate":null,"effect":"Intraocular pressure elevation"},{"rate":null,"effect":"Endophthalmitis"}]},"_chembl":{"chemblId":"CHEMBL1742982","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aflibercept acts as a soluble decoy receptor that traps VEGF-A, VEGF-B, and PlGF in the vitreous, preventing these growth factors from activating their endogenous receptors on retinal vascular endothelial cells. By blocking VEGF signaling, it reduces pathological neovascularization and vascular permeability in retinal diseases. This mechanism stabilizes or improves vision in conditions characterized by abnormal retinal angiogenesis and edema.","oneSentence":"Aflibercept is a recombinant fusion protein that binds vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) to inhibit abnormal blood vessel growth in the retina.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:04:42.474Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neovascular (wet) age-related macular degeneration"},{"name":"Diabetic macular edema"},{"name":"Retinal vein occlusion"},{"name":"Diabetic retinopathy"}]},"trialDetails":[{"nctId":"NCT05710471","phase":"PHASE4","title":"Treatment of Recalcitrant Neovascular AMD Using Brolocizumab With Immediate T&E","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2022-07-25","conditions":"Age-Related Macular Degeneration","enrollment":30},{"nctId":"NCT02120950","phase":"PHASE4","title":"Aflibercept in Polypoidal Choroidal Vasculopathy","status":"COMPLETED","sponsor":"Bayer","startDate":"2014-05-29","conditions":"Neovascular Macular Degeneration","enrollment":333},{"nctId":"NCT02072408","phase":"PHASE4","title":"Efficacy and Safety of Intravitreal Vascular Endothelial Growth Factor Trap-eye in Patients With Polyploidal Choroidal Vasculopathy","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2014-02","conditions":"Polypoidal Choroidal Vasculopathy Without Active Polyp","enrollment":46},{"nctId":"NCT01521559","phase":"PHASE3","title":"Study to Assess the Clinical Efficacy and Safety of Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321) in Patients With Branch Retinal Vein Occlusion (BRVO)","status":"COMPLETED","sponsor":"Regeneron Pharmaceuticals","startDate":"2012-04","conditions":"Branch Retinal Vein Occlusion","enrollment":183},{"nctId":"NCT02092532","phase":"PHASE4","title":"Intravitreal Aflibercept for Neovascular Polypoidal Choroidal Vasculopathy (RIVAL Trial)","status":"UNKNOWN","sponsor":"Southeast Retina Center, Georgia","startDate":"2014-03","conditions":"Neovascular Polypoidal Choroidal Vasculopathy","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Rescue Intravitreal Aflibercept Injection","genericName":"Rescue Intravitreal Aflibercept Injection","companyName":"Southeast Retina Center, Georgia","companyId":"southeast-retina-center-georgia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aflibercept is a recombinant fusion protein that binds vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) to inhibit abnormal blood vessel growth in the retina. Used for Neovascular (wet) age-related macular degeneration, Diabetic macular edema, Retinal vein occlusion.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}