{"id":"repirinast","rwe":[],"tags":[{"label":"repirinast","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Immunologic Factors","category":"pharmacology"},{"label":"Immunosuppressive Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"romet","offLabel":[],"synonyms":["repirinast","romet"],"timeline":[],"approvals":[],"brandName":"Romet","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"repirinast","explanation":"Think of it like a fire alarm in a building. When there's a fire, the alarm goes off to alert people to get out. Inflammation is like a fire in the body, and the enzyme Romet targets is like the alarm that makes the fire worse. By turning off this alarm, Romet helps reduce the inflammation and its associated symptoms.","oneSentence":"Romet works by inhibiting the activity of a specific enzyme involved in the inflammatory response.","technicalDetail":"Romet is a selective inhibitor of phosphodiesterase 4 (PDE4), an enzyme involved in the regulation of inflammatory responses through the modulation of cyclic adenosine monophosphate (cAMP) levels."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2367","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=REPIRINAST","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:34:15.317211","biosimilars":[],"competitors":[],"genericName":"repirinast","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"4K8KA8B61G","CHEBI":"CHEBI:32092","INN_ID":"5939","UMLSCUI":"C0073071","ChEMBL_ID":"CHEMBL2105300","KEGG_DRUG":"D01890","PUBCHEM_CID":"5050","MESH_SUPPLEMENTAL_RECORD_UI":"C048522"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":20,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Romet, also known as Repirinast, is a small molecule. It has multiple synonyms, including MY-5116 and Repirinast.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}