{"id":"remikiren","rwe":[],"tags":[{"label":"remikiren","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Renin","category":"target"},{"label":"REN","category":"gene"},{"label":"C09XA01","category":"atc"},{"label":"Active","category":"status"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Protease Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ro 42-5892","offLabel":[],"synonyms":["remikiren","Ro 42-5892","Ro-42-5892"],"timeline":[],"approvals":[],"brandName":"Ro 42-5892","ecosystem":[],"mechanism":{"target":"Renin","targets":[{"gene":"REN","source":"DrugCentral","target":"Renin","protein":"Renin"}],"modality":"Small Molecule","drugClass":"remikiren","explanation":"Think of the RAAS like a chain reaction that helps control blood pressure. Remikiren steps in and blocks the first link in this chain, the renin enzyme, which helps to slow down the reaction and lower blood pressure. This can be beneficial for people with conditions like hypertension.","oneSentence":"Remikiren works by directly inhibiting the renin enzyme, which plays a key role in the renin-angiotensin-aldosterone system (RAAS) that regulates blood pressure.","technicalDetail":"Remikiren acts as a competitive inhibitor of the renin enzyme, specifically binding to the active site and preventing the conversion of angiotensinogen to angiotensin I, thereby reducing the production of angiotensin II and aldosterone."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4696","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=REMIKIREN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:34:12.140833","biosimilars":[],"competitors":[{"drugName":"aliskiren","drugSlug":"aliskiren","fdaApproval":"2007-03-05","patentExpiry":"Feb 19, 2026","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"hydrochlorothiazide","drugSlug":"hydrochlorothiazide","fdaApproval":"1959-02-12","patentExpiry":"Jan 23, 2044","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"amlodipine","drugSlug":"amlodipine","fdaApproval":"1992-07-31","patentExpiry":"Feb 24, 2041","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"remikiren","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"aliskiren","brandName":"aliskiren","genericName":"aliskiren","approvalYear":"2007","relationship":"same-class"},{"drugId":"hydrochlorothiazide","brandName":"hydrochlorothiazide","genericName":"hydrochlorothiazide","approvalYear":"1959","relationship":"same-class"},{"drugId":"amlodipine","brandName":"amlodipine","genericName":"amlodipine","approvalYear":"1992","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"LC7FBL96A4","CHEBI":"CHEBI:8803","INN_ID":"6876","UMLSCUI":"C0209499","ChEMBL_ID":"CHEMBL31601","KEGG_DRUG":"D09038","DRUGBANK_ID":"DB00212","PDB_CHEM_ID":" REM","PUBCHEM_CID":"6324659","MESH_SUPPLEMENTAL_RECORD_UI":"C065581"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"5.2 hours","clearance":"11.6 mL/min/kg","bioavailability":"1%","fractionUnbound":"0.05581288827%","volumeOfDistribution":"0.77 L/kg"},"publicationCount":37,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C09XA01","allCodes":["C09XA01"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ro 42-5892 is a small molecule with the synonyms REMIKIREN, REMIKIRENE, REMIKIRENO, and others.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}