{"id":"remifentanil-propofol-and-citanest","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Injection site pain"}]},"_chembl":{"chemblId":"CHEMBL526","moleculeType":"Small molecule","molecularWeight":"178.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Remifentanil is an opioid agonist that provides analgesia and sedation by binding to mu opioid receptors. Propofol is a sedative-hypnotic that enhances GABA-mediated inhibition in the central nervous system. Prilocaine (citanest) is a local anesthetic that blocks sodium channels in nerve membranes. Together, they provide rapid induction and maintenance of general anesthesia with analgesia.","oneSentence":"This is a combination of three anesthetic agents that work synergistically to induce and maintain general anesthesia through different mechanisms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:04:37.529Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia for surgical procedures"}]},"trialDetails":[{"nctId":"NCT01412632","phase":"PHASE4","title":"Comparing Two Types of Sedation to Gynaecological Patients","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2011-11","conditions":"Transcervical Resection of Endometrium, Transcervical Resection of Fibroids, Transcervical Resection of Polyp","enrollment":153}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Remifentanil, propofol and citanest","genericName":"Remifentanil, propofol and citanest","companyName":"University of Aarhus","companyId":"university-of-aarhus","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of three anesthetic agents that work synergistically to induce and maintain general anesthesia through different mechanisms. Used for Induction and maintenance of general anesthesia for surgical procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}