{"id":"remifentanil-adapted-to-spi","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Muscle rigidity"},{"rate":null,"effect":"Nausea and vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Remifentanil activates mu-opioid receptors in the central nervous system to produce analgesia and sedation. The SPI adaptation represents a closed-loop or guided dosing approach where the Surgical Pleth Index—a non-invasive measure of nociception derived from photoplethysmography—is used to titrate remifentanil dosing in real-time during anesthesia, aiming to optimize pain control while minimizing overdosing.","oneSentence":"Remifentanil is a potent opioid agonist that binds to mu-opioid receptors to provide rapid-onset, short-acting analgesia and sedation, with dosing adapted to Surgical Pleth Index (SPI) for real-time pain monitoring.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:04:39.855Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intraoperative analgesia and sedation during general anesthesia, guided by Surgical Pleth Index monitoring"}]},"trialDetails":[{"nctId":"NCT03586791","phase":"NA","title":"Comparison of Pupillometry-guided Anesthesia With Surgical Pleth Index Guided Anesthesia","status":"COMPLETED","sponsor":"Daegu Catholic University Medical Center","startDate":"2018-07-11","conditions":"Cholecystectomy, Laparoscopic, Anesthesia, General, Reflex, Pupillary","enrollment":50},{"nctId":"NCT02429960","phase":"NA","title":"Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations","status":"COMPLETED","sponsor":"Universitätsklinikum Hamburg-Eppendorf","startDate":"2015-04","conditions":"Anesthesia","enrollment":30},{"nctId":"NCT03794271","phase":"NA","title":"Effect of Pupilometer Guided Analgesia on Postoperative Pain","status":"COMPLETED","sponsor":"Daegu Catholic University Medical Center","startDate":"2019-01-03","conditions":"Cholecystectomy, Laparoscopic, Anesthesia, General, Reflex, Pupillary","enrollment":84},{"nctId":"NCT03380949","phase":"NA","title":"Monitor-Guided Analgesia During General Anesthesia - Part II","status":"COMPLETED","sponsor":"Universitätsklinikum Hamburg-Eppendorf","startDate":"2017-12-08","conditions":"Pain, Postoperative, Pain, Nociceptive Pain","enrollment":96},{"nctId":"NCT02884310","phase":"PHASE4","title":"Interest of a Tetanus Test at a Fixed Remifentanil Concentration Before Laryngoscopy and Skin Incision","status":"COMPLETED","sponsor":"Erasme University Hospital","startDate":"2013-01","conditions":"Intravenous Anesthetic Agent Overdose","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Remifentanil adapted to SPI","genericName":"Remifentanil adapted to SPI","companyName":"Erasme University Hospital","companyId":"erasme-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Remifentanil is a potent opioid agonist that binds to mu-opioid receptors to provide rapid-onset, short-acting analgesia and sedation, with dosing adapted to Surgical Pleth Index (SPI) for real-time pain monitoring. Used for Intraoperative analgesia and sedation during general anesthesia, guided by Surgical Pleth Index monitoring.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}