{"id":"rematazolam-besylate","safety":{"commonSideEffects":[{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a benzodiazepine, rematazolam besylate potentiates the inhibitory effects of GABA at GABA-A receptors, leading to increased chloride ion influx and neuronal hyperpolarization. This results in sedative, anxiolytic, and anticonvulsant effects. The drug is designed for rapid onset and short duration of action, making it suitable for procedural sedation and acute anxiety management.","oneSentence":"Rematazolam besylate is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors in the central nervous system.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:04:38.971Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Procedural sedation"},{"name":"Acute anxiety and agitation"}]},"trialDetails":[{"nctId":"NCT05624424","phase":"PHASE4","title":"Effect of Rematazolam Besylate, Propofol, and Sevoflurane Perioperative Sedation on Incidence of Emergence Agitation and Hemodynamics in Patients Undergoing Laparoscopic Abdominal Surgery","status":"UNKNOWN","sponsor":"Second Affiliated Hospital of Nanchang University","startDate":"2022-11-15","conditions":"Emergence Agitation, Remimazolam Besylate, Perioperative Sedation","enrollment":1317}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":783,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Rematazolam Besylate","genericName":"Rematazolam Besylate","companyName":"Second Affiliated Hospital of Nanchang University","companyId":"second-affiliated-hospital-of-nanchang-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rematazolam besylate is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors in the central nervous system. Used for Procedural sedation, Acute anxiety and agitation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}