{"id":"regimen-tdf-3tc-efv","safety":{"commonSideEffects":[{"rate":"20-50","effect":"Neuropsychiatric effects (dizziness, impaired concentration, abnormal dreams)"},{"rate":"10-20","effect":"Rash"},{"rate":"10-15","effect":"Nausea"},{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Elevated liver enzymes"},{"rate":"1-5","effect":"Renal dysfunction (TDF-related)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"TDF (tenofovir disoproxil fumarate) and 3TC (lamivudine) are nucleoside reverse transcriptase inhibitors that block HIV reverse transcriptase, while EFV (efavirenz) is a non-nucleoside reverse transcriptase inhibitor that also targets the same enzyme through a different mechanism. Together, these three agents suppress HIV replication by preventing the conversion of viral RNA to DNA and integration into the host genome.","oneSentence":"This combination regimen inhibits HIV reverse transcriptase and integrase through three antiretroviral agents, preventing viral replication and reducing viral load.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:37:05.685Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV-1 infection (treatment)"}]},"trialDetails":[{"nctId":"NCT01751555","phase":"PHASE4","title":"Efficacy and Safety of TDF+3TC+EFV in Adults With HIV/HBV Coinfection","status":"COMPLETED","sponsor":"National Center for AIDS/STD Control and Prevention, China CDC","startDate":"2011-02","conditions":"Hiv","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":49,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Regimen:TDF+3TC+EFV","genericName":"Regimen:TDF+3TC+EFV","companyName":"National Center for AIDS/STD Control and Prevention, China CDC","companyId":"national-center-for-aids-std-control-and-prevention-china-cdc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination regimen inhibits HIV reverse transcriptase and integrase through three antiretroviral agents, preventing viral replication and reducing viral load. Used for HIV-1 infection (treatment).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}