{"id":"regimen-bic-ftc-taf","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Elevated creatinine"}]},"_chembl":{"chemblId":"CHEMBL262331","moleculeType":"Small molecule","molecularWeight":"476.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bictegravir (BIC) is an integrase strand transfer inhibitor that blocks HIV integration into host DNA. Emtricitabine (FTC) and tenofovir alafenamide (TAF) are nucleoside/nucleotide reverse transcriptase inhibitors that prevent viral RNA-to-DNA conversion. Together, these three agents target different steps of the HIV replication cycle to achieve potent viral suppression.","oneSentence":"This combination regimen inhibits HIV reverse transcriptase and integrase to suppress viral replication and prevent AIDS progression.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:04:26.106Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV-1 infection in treatment-naïve and treatment-experienced adults"},{"name":"HIV-1 infection in adolescents and children (weight-based dosing)"}]},"trialDetails":[{"nctId":"NCT06830668","phase":"PHASE4","title":"Same-Day Restart of B/F/TAF in HIV Patients After NNRTI Discontinuation","status":"NOT_YET_RECRUITING","sponsor":"National Center for AIDS/STD Control and Prevention, China CDC","startDate":"2025-02-28","conditions":"HIV Infection, HIV","enrollment":250}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Regimen：BIC+FTC+TAF","genericName":"Regimen：BIC+FTC+TAF","companyName":"National Center for AIDS/STD Control and Prevention, China CDC","companyId":"national-center-for-aids-std-control-and-prevention-china-cdc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"The regimen BIC+FTC+TAF is used to treat HIV infection. BIC, FTC, and TAF are small molecule drugs that work together to combat HIV.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}