{"id":"regenexx-sd-procedure","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Temporary increase in joint pain"},{"rate":null,"effect":"Infection at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The procedure involves harvesting bone marrow from the patient, concentrating stem cells and growth factors, and injecting them directly into damaged joints. These stem cells are believed to differentiate into cartilage-forming cells, reduce inflammatory cytokines, and stimulate the body's natural healing response to repair degenerative tissue.","oneSentence":"Regenexx SD uses autologous bone marrow-derived stem cells to promote tissue regeneration and reduce inflammation in degenerative joint conditions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:31:52.608Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis of the knee"},{"name":"Osteoarthritis of the hip"},{"name":"Osteoarthritis of the shoulder"},{"name":"Degenerative disc disease of the spine"}]},"trialDetails":[{"nctId":"NCT02848027","phase":"PHASE3","title":"Correlating the Osteoarthritic Knee Microenvironment to Clinical Outcome After Treatment With Regenexx®SD Treatment","status":"COMPLETED","sponsor":"Regenexx, LLC","startDate":"2015-09-08","conditions":"Osteoarthritis, Knee","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Regenexx SD® procedure","genericName":"Regenexx SD® procedure","companyName":"Regenexx, LLC","companyId":"regenexx-llc","modality":"Biologic","firstApprovalDate":"","aiSummary":"Regenexx SD uses autologous bone marrow-derived stem cells to promote tissue regeneration and reduce inflammation in degenerative joint conditions. Used for Osteoarthritis of the knee, Osteoarthritis of the hip, Osteoarthritis of the shoulder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}