{"id":"refresh-optive-ud","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Eye discomfort"}]},"_chembl":{"chemblId":"CHEMBL24646","moleculeType":"Small molecule","molecularWeight":"334.38"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a multi-ingredient ophthalmic lubricant containing carboxymethylcellulose sodium, glycerin, and polysorbate 80 that mimics natural tears. It works by providing sustained lubrication to the cornea and conjunctiva, reducing friction and protecting against further desiccation in dry eye disease. The formulation is preservative-free (UD = unit dose) to minimize ocular irritation.","oneSentence":"REFRESH OPTIVE UD is an artificial tear solution that lubricates and protects the ocular surface to relieve dry eye symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:52:18.817Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease / Keratoconjunctivitis sicca"}]},"trialDetails":[{"nctId":"NCT07284381","phase":"PHASE3","title":"A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease","status":"RECRUITING","sponsor":"AbbVie","startDate":"2025-12-15","conditions":"Dry Eye Disease","enrollment":250},{"nctId":"NCT06443775","phase":"","title":"An Observational Study to Assess Next Generation Emulsion Preservative Free Eye Drops (NGE-UD) on Dry Eye Symptoms and Quality of Life of Adult Participants With Mild to Moderate Dry Eye Disease (DED)","status":"COMPLETED","sponsor":"AbbVie","startDate":"2024-06-17","conditions":"Dry Eye","enrollment":47}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"REFRESH OPTIVE UD","genericName":"REFRESH OPTIVE UD","companyName":"AbbVie","companyId":"abbvie","modality":"Small molecule","firstApprovalDate":"","aiSummary":"REFRESH OPTIVE UD is an artificial tear solution that lubricates and protects the ocular surface to relieve dry eye symptoms. Used for Dry eye disease / Keratoconjunctivitis sicca.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}