{"id":"reference-tazorac-cream-0-05","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Skin irritation"},{"rate":"5-10%","effect":"Dryness"},{"rate":"5-10%","effect":"Redness"}]},"_chembl":{"chemblId":"CHEMBL2108947","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It does this by binding to retinoic acid receptors, which are involved in regulating cell growth and differentiation. This leads to an increase in the rate of cell turnover, which helps to unclog pores and reduce inflammation. Additionally, it prevents the formation of comedones, which are a key factor in the development of acne.","oneSentence":"Tazorac Cream, 0.05% is a topical retinoid that works by promoting cell turnover and preventing the formation of comedones, thereby reducing acne severity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:31:42.092Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT02886702","phase":"PHASE3","title":"A Study Comparing Tazarotene Cream 0.05% to TAZORAC® (Tazarotene) Cream 0.05% and Both to a Placebo Control in the Treatment of Plaque Psoriasis","status":"COMPLETED","sponsor":"Fougera Pharmaceuticals Inc.","startDate":"2016-09-19","conditions":"Plaque Psoriasis","enrollment":855},{"nctId":"NCT02160665","phase":"PHASE3","title":"Generic Tazarotene Cream, 0.05% for the Treatment of Plaque Psoriasis","status":"COMPLETED","sponsor":"G & W Laboratories Inc.","startDate":"2014-05","conditions":"Plaque Psoriasis","enrollment":866}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tazorac"],"phase":"phase_3","status":"active","brandName":"Reference: Tazorac Cream, 0.05%","genericName":"Reference: Tazorac Cream, 0.05%","companyName":"G & W Laboratories Inc.","companyId":"g-w-laboratories-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tazorac Cream, 0.05% is a topical retinoid that works by promoting cell turnover and preventing the formation of comedones, thereby reducing acne severity. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}