{"id":"reference-metronidazole-gel-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or burning"},{"rate":null,"effect":"Metallic taste (systemic formulations)"},{"rate":null,"effect":"Local erythema or pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metronidazole is reduced by anaerobic organisms and protozoa to form reactive intermediates that damage DNA and inhibit nucleic acid synthesis. The drug is selectively toxic to anaerobic microorganisms because it requires anaerobic conditions for activation. It is commonly used topically as a gel formulation for localized treatment of infections and inflammatory conditions.","oneSentence":"Metronidazole is a nitroimidazole antibiotic that disrupts bacterial and protozoal DNA by generating reactive free radicals, leading to cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:31:44.235Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial vaginosis"},{"name":"Rosacea"},{"name":"Anaerobic bacterial infections (topical)"}]},"trialDetails":[{"nctId":"NCT02393937","phase":"PHASE3","title":"A Therapeutic Equivalence Study of Two Metronidazole Gel 1% Topical Treatments of Rosacea","status":"COMPLETED","sponsor":"bioRASI, LLC","startDate":"2015-02","conditions":"Papulopustular Rosacea, Erythematotelangiectatic Rosacea","enrollment":963}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MetroGel"],"phase":"phase_3","status":"active","brandName":"Reference: Metronidazole Gel 1%","genericName":"Reference: Metronidazole Gel 1%","companyName":"bioRASI, LLC","companyId":"biorasi-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metronidazole Gel 1% is used to treat Papulopustular Rosacea and Erythematotelangiectatic Rosacea. It works as a small molecule DNA inhibitor.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}