{"id":"reducing-anticholinergic-burden","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL3037806","moleculeType":"Small molecule","molecularWeight":"326.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Anticholinergic medications block acetylcholine receptors and can cause cognitive impairment, urinary retention, constipation, and increased fall risk, particularly in elderly patients. Reducing anticholinergic burden is a deprescribing strategy that systematically identifies and removes or replaces anticholinergic drugs with safer alternatives. This approach improves patient safety and reduces adverse outcomes associated with high anticholinergic exposure.","oneSentence":"Reducing anticholinergic burden involves discontinuing or deprescribing medications with anticholinergic properties to minimize cumulative anticholinergic effects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:04:23.280Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of anticholinergic medication burden in elderly or polypharmacy patients"},{"name":"Prevention of cognitive decline and delirium in older adults"},{"name":"Reduction of fall risk and urinary retention in patients on multiple anticholinergic agents"}]},"trialDetails":[{"nctId":"NCT06349057","phase":"PHASE4","title":"The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-01-01","conditions":"Postoperative Recovery, Length of Hospital Stay, Postoperative Complications","enrollment":120},{"nctId":"NCT06248723","phase":"NA","title":"ItaliaN Study With Tailored Multidomain Interventions to Prevent Functional and Cognitive Decline in Community-dwelling Older Adults","status":"RECRUITING","sponsor":"University of Milano Bicocca","startDate":"2024-07-16","conditions":"Age-related Cognitive Decline","enrollment":1340},{"nctId":"NCT05735379","phase":"PHASE4","title":"Impact in Older Adults of Reducing Anticholinergic and Sedative Rx Burden on Physical Function Measured by Wearables","status":"UNKNOWN","sponsor":"Centre de recherche du Centre hospitalier universitaire de Sherbrooke","startDate":"2023-03-23","conditions":"Deprescribing Anticholinergic and Sedative Medications, Physical Function","enrollment":182},{"nctId":"NCT00715377","phase":"NA","title":"Anticholinergic Burden in Schizophrenia","status":"TERMINATED","sponsor":"Centre for Addiction and Mental Health","startDate":"2007-06","conditions":"Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder","enrollment":2}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":151,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["not reducing anticholinergic burden, routine care"],"phase":"marketed","status":"active","brandName":"reducing anticholinergic burden","genericName":"reducing anticholinergic burden","companyName":"Ankara City Hospital Bilkent","companyId":"ankara-city-hospital-bilkent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Reducing anticholinergic burden has been studied in various conditions, including postoperative recovery, complications, and physical function, with interventions such as deprescribing anticholinergic and sedative medications. A randomized controlled study (NCT06349057) investigated anticholinergic burden as a modifiable risk factor in cardiac surgery, suggesting its potential impact on patient outcomes.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}