{"id":"reduced-nicotine-content-cigars","safety":{"commonSideEffects":[{"rate":null,"effect":"Withdrawal symptoms (if used as cessation aid)"},{"rate":null,"effect":"Continued tobacco-related health risks"}]},"_chembl":{"chemblId":"CHEMBL3989563","moleculeType":"Small molecule","molecularWeight":"498.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By reducing nicotine concentration in cigars, this product aims to decrease nicotine addiction potential while allowing continued use, similar to nicotine reduction strategies in cigarettes. The lower nicotine content may reduce cardiovascular and neurological effects of nicotine while maintaining behavioral/sensory aspects of cigar use. This is a harm-reduction rather than cessation-focused approach.","oneSentence":"Reduced nicotine content cigars lower the addictive nicotine dose delivered per cigar to decrease dependence and tobacco-related harm.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:04:26.471Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nicotine dependence reduction in cigar users"},{"name":"Tobacco harm reduction"}]},"trialDetails":[{"nctId":"NCT06630728","phase":"PHASE4","title":"Addiction Potential of Very Low Nicotine Filtered Little Cigars","status":"RECRUITING","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2025-02-13","conditions":"Smoking (Tobacco) Addiction","enrollment":50},{"nctId":"NCT02000921","phase":"NA","title":"Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2013-12","conditions":"Tobacco Addiction, Dual Tobacco Use","enrollment":136}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["VLNFLC"],"phase":"marketed","status":"active","brandName":"Reduced Nicotine Content Cigars","genericName":"Reduced Nicotine Content Cigars","companyName":"Ohio State University Comprehensive Cancer Center","companyId":"ohio-state-university-comprehensive-cancer-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Reduced nicotine content cigars lower the addictive nicotine dose delivered per cigar to decrease dependence and tobacco-related harm. Used for Nicotine dependence reduction in cigar users, Tobacco harm reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}