{"id":"red-yeast-rice-pill","safety":{"commonSideEffects":[{"rate":null,"effect":"Myalgia (muscle pain)"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Rhabdomyolysis (rare)"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":{"chemblId":"CHEMBL2108007","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Red yeast rice is a fermented product of rice colonized by Monascus purpureus that produces monacolin K (lovastatin) and other statin-like compounds. These active constituents competitively inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, thereby lowering LDL cholesterol and total cholesterol levels. The product also contains other bioactive compounds including unsaturated fatty acids and phytosterols that may contribute to lipid-lowering effects.","oneSentence":"Red yeast rice contains naturally occurring statins that inhibit HMG-CoA reductase, reducing cholesterol synthesis in the liver.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:04:22.611Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypercholesterolemia and dyslipidemia"},{"name":"Cardiovascular disease prevention"}]},"trialDetails":[{"nctId":"NCT05095480","phase":"PHASE4","title":"Effect of Red Yeast Rice Beside Statin on Lipid Profile","status":"COMPLETED","sponsor":"Shiraz University of Medical Sciences","startDate":"2019-03-01","conditions":"Hyperlipidemias","enrollment":92},{"nctId":"NCT04433429","phase":"","title":"Nutraceuticals and Vascular Remodelling","status":"COMPLETED","sponsor":"Marcello Rattazzi","startDate":"2016-05","conditions":"Hypercholesterolemia","enrollment":30},{"nctId":"NCT03607383","phase":"PHASE2","title":"Red Rice Yeast in Low-density Lipoprotein (LDL) Lowering: an Efficacy Study","status":"UNKNOWN","sponsor":"Saint-Joseph University","startDate":"2018-02-07","conditions":"Dyslipidemias, LDL Hyperlipoproteinemia","enrollment":40},{"nctId":"NCT02142569","phase":"PHASE2, PHASE3","title":"Effects of a Supplement Derived From Palm Oil on Cholesterol Levels and Chinese Red Yeast Rice in the Blood","status":"WITHDRAWN","sponsor":"University of California, Los Angeles","startDate":"2013-10-30","conditions":"Cholesterol Lowering","enrollment":""},{"nctId":"NCT03470376","phase":"PHASE4","title":"NUtraceutical TReatment for hYpercholesterolemia in HIV-infected Patients","status":"COMPLETED","sponsor":"University Of Perugia","startDate":"2017-01-15","conditions":"Hypercholesterolemia, Inflammation, Atherosclerosis","enrollment":26},{"nctId":"NCT02001883","phase":"PHASE4","title":"Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients","status":"UNKNOWN","sponsor":"University of Roma La Sapienza","startDate":"2013-11","conditions":"Coronary Artery Disease","enrollment":100},{"nctId":"NCT01490229","phase":"PHASE4","title":"Ezetimibe Versus Nutraceuticals in Statin-intolerant Patients","status":"UNKNOWN","sponsor":"University of Roma La Sapienza","startDate":"2013-01","conditions":"Coronary Artery Disease","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lesstat"],"phase":"marketed","status":"active","brandName":"Red Yeast Rice Pill","genericName":"Red Yeast Rice Pill","companyName":"Shiraz University of Medical Sciences","companyId":"shiraz-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Red yeast rice contains naturally occurring statins that inhibit HMG-CoA reductase, reducing cholesterol synthesis in the liver. Used for Hypercholesterolemia and dyslipidemia, Cardiovascular disease prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}