{"id":"red-yeast-rice-and-atorvastatin","safety":{"commonSideEffects":[{"rate":null,"effect":"Myalgia (muscle pain)"},{"rate":null,"effect":"Elevated liver enzymes"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Rhabdomyolysis (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Red yeast rice contains naturally occurring statins (primarily monacolin K, which is structurally identical to lovastatin) that inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Atorvastatin is a synthetic statin that works through the same mechanism. The combination leverages both natural and pharmaceutical statin activity to achieve enhanced lipid-lowering effects with potentially improved tolerability or efficacy compared to either agent alone.","oneSentence":"Red yeast rice and atorvastatin work synergistically to inhibit HMG-CoA reductase and reduce cholesterol synthesis, lowering LDL cholesterol and cardiovascular risk.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:31:44.238Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypercholesterolemia and dyslipidemia management"},{"name":"Cardiovascular disease prevention"}]},"trialDetails":[{"nctId":"NCT05845580","phase":"NA","title":"Patient Autonomy and Statin Therapy Adherence","status":"COMPLETED","sponsor":"Lithuanian University of Health Sciences","startDate":"2023-06-01","conditions":"Drug Adherence","enrollment":300},{"nctId":"NCT02726555","phase":"PHASE3","title":"The Efficacy and Safety of Combined Therapy With Red Yeast Rice and Low-dose Statin：Comparing With Standardized Statin","status":"RECRUITING","sponsor":"Wenzhou Medical University","startDate":"2015-11","conditions":"Dyslipidemia, Atherosclerosis","enrollment":240},{"nctId":"NCT02001883","phase":"PHASE4","title":"Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients","status":"UNKNOWN","sponsor":"University of Roma La Sapienza","startDate":"2013-11","conditions":"Coronary Artery Disease","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Xuezhikang; Lipitor"],"phase":"phase_3","status":"active","brandName":"Red yeast rice and atorvastatin","genericName":"Red yeast rice and atorvastatin","companyName":"Wenzhou Medical University","companyId":"wenzhou-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Red yeast rice and atorvastatin work synergistically to inhibit HMG-CoA reductase and reduce cholesterol synthesis, lowering LDL cholesterol and cardiovascular risk. Used for Hypercholesterolemia and dyslipidemia management, Cardiovascular disease prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}