{"id":"red-blood-cell-transfusion-trigger","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Hypotension"},{"rate":"5-10%","effect":"Allergic reactions"},{"rate":"5-10%","effect":"Fever"},{"rate":"5-10%","effect":"Nausea and vomiting"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2108195","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This process is typically performed in patients with severe anemia or blood loss due to trauma, surgery, or other medical conditions. The transfused red blood cells help to restore normal red blood cell function and alleviate symptoms such as fatigue, shortness of breath, and dizziness.","oneSentence":"Red blood cell transfusions involve the transfer of red blood cells from a donor to a patient to increase red blood cell count and improve oxygen delivery to tissues.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:52:18.765Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of anemia due to chronic kidney disease"},{"name":"Treatment of anemia due to cancer chemotherapy"}]},"trialDetails":[{"nctId":"NCT03369210","phase":"PHASE3","title":"Liberal Transfusion Strategy in Elderly Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johann Wolfgang Goethe University Hospital","startDate":"2017-12-04","conditions":"Transfusion-dependent Anemia, Surgery, Anemia","enrollment":2470},{"nctId":"NCT06718439","phase":"NA","title":"Hemoglobin Levels for Blood Transfusions 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Gotha/Ohrdruf","startDate":"2024-09-01","conditions":"Major Surgery","enrollment":25979},{"nctId":"NCT06560164","phase":"NA","title":"Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO","status":"RECRUITING","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2024-11-26","conditions":"Transfusion, Red Blood Cell, Extracorporeal Membrane Oxygenation","enrollment":526},{"nctId":"NCT03309579","phase":"NA","title":"SAHaRA: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2018-02-12","conditions":"Subarachnoid Hemorrhage, Aneurysmal","enrollment":742},{"nctId":"NCT01345643","phase":"NA","title":"Clinical Trial of West-China Perioperative Transfusion Score (WCPTS）for Massive Hemorrhagic Surgery","status":"COMPLETED","sponsor":"Ren Liao","startDate":"2011-02","conditions":"Transfusion Related Complications","enrollment":190},{"nctId":"NCT06332547","phase":"NA","title":"Transfusion in Cardiac Valve Surgery","status":"NOT_YET_RECRUITING","sponsor":"Guangdong Provincial People's Hospital","startDate":"2024-04-01","conditions":"Cardiac Surgery With Cardiopulmonary Bypass, Valve Heart Disease","enrollment":1600},{"nctId":"NCT06103214","phase":"NA","title":"The Effects of Hemodilution Methods in Patients Undergoing Primary Debulking Gynaecological Surgery","status":"COMPLETED","sponsor":"Zhejiang Cancer Hospital","startDate":"2017-01-01","conditions":"Ovarian Neoplasm Epithelial","enrollment":144},{"nctId":"NCT04537000","phase":"NA","title":"Individualized Strategies of Red Blood Cell Transfusion for Perioperative Pediatric Patients","status":"WITHDRAWN","sponsor":"Children's Hospital of Fudan University","startDate":"2021-05","conditions":"Individualized Transfusion Strategy, Red Blood Cell, Perioperative Pediatric 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Clinic","startDate":"2007-03","conditions":"Anemia","enrollment":722},{"nctId":"NCT02761564","phase":"NA","title":"SvO2 Trigger in Transfusion Strategy After Cardiac Surgery","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2016-10-06","conditions":"Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure), Anemia (<9g/dL) Requiring Blood Transfusion","enrollment":100},{"nctId":"NCT02535208","phase":"NA","title":"Combining Restrictive Guidelines and a NIRS SCORE to Decrease RBC Transfusions","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2016-05-16","conditions":"Anemia of Prematurity (AOP)","enrollment":10},{"nctId":"NCT02483351","phase":"PHASE2, PHASE3","title":"Aneurysmal Subarachnoid Hemorrhage: Red Blood Cell Transfusion and Outcome","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2015-10","conditions":"Subarachnoid 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Transfusion Triggers in Patients Undergoing Hematopoietic Stem Cell Transplantation","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2011-03","conditions":"Hematologic Malignancies","enrollment":300},{"nctId":"NCT01895205","phase":"PHASE3","title":"Treatment of Women After Severe Postpartum Haemorrhage","status":"COMPLETED","sponsor":"Pharmacosmos A/S","startDate":"2013-06","conditions":"Severe Postpartum Haemorrhage","enrollment":13},{"nctId":"NCT00470444","phase":"NA","title":"Transfusion Triggers in Cardiac Surgery","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2006-12","conditions":"Cardiac Surgery","enrollment":50},{"nctId":"NCT02139995","phase":"PHASE3","title":"West-China Transfusion Score for Critically-ill Patients","status":"UNKNOWN","sponsor":"West China Hospital","startDate":"2014-05","conditions":"Transfusion Related Complication, Critical Illness","enrollment":100},{"nctId":"NCT01484639","phase":"NA","title":"Transfusion Requirements in Cardiac Surgery","status":"COMPLETED","sponsor":"Nadine Shehata","startDate":"2012-01","conditions":"Cardiac Surgery","enrollment":208}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"red blood cell transfusion trigger","genericName":"red blood cell transfusion trigger","companyName":"Johann Wolfgang Goethe University Hospital","companyId":"johann-wolfgang-goethe-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Red blood cell transfusions are typically considered for patients with a hematocrit value less than 24%. This threshold is based on a restrictive transfusion strategy, as seen in the \"Restrictive Transfusion Strategy Early After Cardiac Surgery\" study (NCT02761564).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}