{"id":"recombinant-human-growth-hormone","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Carpal tunnel syndrome"},{"rate":null,"effect":"Fluid retention"},{"rate":null,"effect":"Arthralgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This recombinant protein mimics endogenous human growth hormone by activating the growth hormone receptor, a transmembrane receptor that triggers intracellular signaling cascades. This leads to increased insulin-like growth factor 1 (IGF-1) production, enhanced protein synthesis, lipolysis, and linear growth in children. The drug restores physiological growth hormone levels in deficient patients.","oneSentence":"Recombinant human growth hormone binds to growth hormone receptors on target cells to stimulate growth, metabolism, and protein synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:04:18.293Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Growth hormone deficiency in children"},{"name":"Growth hormone deficiency in adults"},{"name":"Short stature due to growth hormone insufficiency"},{"name":"Turner syndrome"},{"name":"Chronic kidney disease-related growth failure"}]},"trialDetails":[{"nctId":"NCT07481656","phase":"PHASE4","title":"Effects of Recombinant Human Growth Hormone in Elderly Patients With Moderate to Severe Acute Brain Injury (GH-ABI-RCT)","status":"NOT_YET_RECRUITING","sponsor":"Anhui Provincial Hospital","startDate":"2026-04-10","conditions":"Acute Brain Injuries, Moderate to Severe Traumatic Brain Injury","enrollment":160},{"nctId":"NCT07036003","phase":"PHASE1, PHASE2","title":"Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR)","status":"RECRUITING","sponsor":"Dr. David Wasserstein","startDate":"2025-10-31","conditions":"Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)","enrollment":34},{"nctId":"NCT00663611","phase":"PHASE1","title":"Growth Hormone Administration and the Human Immune System","status":"COMPLETED","sponsor":"National Institute on Aging (NIA)","startDate":"2006-10-19","conditions":"Healthy Volunteers","enrollment":66},{"nctId":"NCT06038539","phase":"PHASE3","title":"Efficacy and Safety of the Proposed Biosimilar Pertuzumab (PERT-IJS) Versus EU-Perjeta® Along With Trastuzumab and Chemotherapy (Carboplatin and Docetaxel) as Neoadjuvant Treatment in Chemotherapy naïve Patients With Early Stage or Locally Advanced HR Negative and HER2 Positive Breast Cancer","status":"TERMINATED","sponsor":"Biocon Biologics UK Ltd","startDate":"2025-01-06","conditions":"HR Negative HER2 Positive Early Breast Cancer or Locally Advanced Breast Cancer Patients","enrollment":55},{"nctId":"NCT06927310","phase":"PHASE3","title":"The Efficacy and Safety of Inpegsomatropin Injection in Children With Idiopathic Short Stature","status":"RECRUITING","sponsor":"Xiamen Amoytop Biotech Co., Ltd.","startDate":"2025-04-28","conditions":"Idiopathic Short Stature","enrollment":300},{"nctId":"NCT06011772","phase":"EARLY_PHASE1","title":"EGF-Depleting Therapy CIMAvax-EGF in Combination With Standard Therapy for RAS- and BRAF Wild-Type Metastatic Colorectal Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Roswell Park Cancer Institute","startDate":"2023-12-18","conditions":"Colo-rectal Cancer","enrollment":2},{"nctId":"NCT07450001","phase":"PHASE1, PHASE2","title":"A Study of GenSci134 in Children With Growth Hormone Deficiency (PGHD)","status":"NOT_YET_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2026-03-06","conditions":"Pediatric Growth Hormone Deficiency","enrollment":128},{"nctId":"NCT07450053","phase":"PHASE1, PHASE2","title":"A Study (Phase 1b/2) of GenSci134 in Children With Idiopathic Short Stature (ISS)","status":"NOT_YET_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2026-03-06","conditions":"Idiopathic Short Stature","enrollment":128},{"nctId":"NCT07309562","phase":"PHASE3","title":"The Efficacy and Safety of Inpegsomatropin Injection in Children With Short Stature Born Small for Gestational Age","status":"RECRUITING","sponsor":"Xiamen Amoytop Biotech Co., Ltd.","startDate":"2026-01-20","conditions":"Small for Gestational Age","enrollment":141},{"nctId":"NCT06668805","phase":"PHASE2","title":"A Basket Study of Vosoritide in Children With Turner Syndrome, Short Stature Homeobox-Containing Gene Deficiency, and Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment","status":"RECRUITING","sponsor":"BioMarin Pharmaceutical","startDate":"2024-11-22","conditions":"Short Stature Homeobox- Containing Gene SHOX Deficiency, Noonan Syndrome, Turner Syndrome","enrollment":54},{"nctId":"NCT03007147","phase":"PHASE3","title":"Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's Oncology Group","startDate":"2017-08-08","conditions":"Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia","enrollment":475},{"nctId":"NCT07260500","phase":"PHASE2","title":"A Phase II Study of PEG-rhGH Injection for Short Children Born Small for Gestational Age: Efficacy, Safety, and Pharmacokinetics","status":"RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-11-11","conditions":"Short Stature Children Born Small for Gestational Age (SGA)","enrollment":72},{"nctId":"NCT07173036","phase":"NA","title":"Evaluation of (Cardio)Metabolic and Auxological Outcomes of GHD Patients Under rhGH or LAGH With Stratification According to IGF-1 Levels","status":"NOT_YET_RECRUITING","sponsor":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","startDate":"2026-03-01","conditions":"Growth Hormone Deficiency","enrollment":300},{"nctId":"NCT06558422","phase":"PHASE1","title":"Human Models of Selective Insulin Resistance: Pancreatic Clamp","status":"NOT_YET_RECRUITING","sponsor":"Columbia University","startDate":"2027-01-01","conditions":"Insulin Resistance, Hyperinsulinemia, Metabolic Dysfunction Associated Steatotic Liver Disease","enrollment":36},{"nctId":"NCT05724134","phase":"PHASE1","title":"Pancreatic Clamp in NAFLD","status":"COMPLETED","sponsor":"Columbia University","startDate":"2023-08-29","conditions":"Insulin Resistance, Prediabetic State, Hyperinsulinemia","enrollment":18},{"nctId":"NCT04867317","phase":"PHASE3","title":"Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2025-01-13","conditions":"Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury","enrollment":172},{"nctId":"NCT04020913","phase":"","title":"Skeletal Muscle Effects of GH in Boys","status":"COMPLETED","sponsor":"Nemours Children's Clinic","startDate":"2019-07-22","conditions":"Growth Hormone Deficiency, Idiopathic Short Stature","enrollment":45},{"nctId":"NCT05602766","phase":"","title":"Ngenla Subcutaneous Injection Special Investigation","status":"ACTIVE_NOT_RECRUITING","sponsor":"Pfizer","startDate":"2023-02-06","conditions":"Growth Hormone Deficiency Without Epiphyseal Closure","enrollment":1},{"nctId":"NCT00861705","phase":"PHASE2","title":"Paclitaxel With or Without Carboplatin and/or Bevacizumab Followed by Doxorubicin and Cyclophosphamide in Treating Patients With Breast Cancer That Can Be Removed by Surgery","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2009-07-21","conditions":"Male Breast Carcinoma, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7","enrollment":454},{"nctId":"NCT03091374","phase":"PHASE2","title":"Impact of Recombinant Human Growth Hormone on HIV Persistence","status":"COMPLETED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2016-12","conditions":"Human Immunodeficiency Virus, Growth Hormone Treatment","enrollment":22},{"nctId":"NCT06037473","phase":"","title":"The Efficacy and Safety of PEGylated GH for the Treatment of Short Stature in Chinese Children-GLOBE Reg","status":"RECRUITING","sponsor":"Beijing Children's Hospital","startDate":"2023-08-01","conditions":"Growth Hormone Treatment, Growth Disorders","enrollment":2600},{"nctId":"NCT06294860","phase":"","title":"Biological Age in Children With GH Deficiency Undergoing Hormone Replacement Therapy","status":"COMPLETED","sponsor":"Istituto Auxologico Italiano","startDate":"2023-06-19","conditions":"Growth Hormone Deficiency, Short Stature","enrollment":10},{"nctId":"NCT03255694","phase":"PHASE2","title":"A Study Extension Period of PEG-somatropin (Pegylated-somatropin) in the Treatment of Children With Idiopathic Short Stature","status":"ACTIVE_NOT_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2017-05-12","conditions":"Dwarfism","enrollment":360},{"nctId":"NCT05355272","phase":"PHASE2","title":"Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)","status":"RECRUITING","sponsor":"Baylor College of Medicine","startDate":"2024-03-11","conditions":"Gulf War Syndrome, Adult Growth Hormone Deficiency","enrollment":20},{"nctId":"NCT06797505","phase":"PHASE1","title":"A Bioequivalence Study of Two Different PEG-rhGH Preparations","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-02-10","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":87},{"nctId":"NCT06732843","phase":"","title":"Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of Cumulus Cells During Antral Follicle Growth and Impact Blastocyst Status?","status":"RECRUITING","sponsor":"ART Fertility Clinics LLC","startDate":"2025-07-23","conditions":"OVARIAN STIMULATION, Telomere Length, Telomere Length, Mean Leukocyte","enrollment":10},{"nctId":"NCT07016802","phase":"PHASE1","title":"A Clinical Study of GenSci134 in Healthy Male Adults","status":"RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-06-23","conditions":"Healthy Volunteers","enrollment":64},{"nctId":"NCT00601900","phase":"PHASE3","title":"Tamoxifen Citrate or Letrozole With or Without Bevacizumab in Treating Women With Stage IIIB or Stage IV Breast Cancer","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2008-09-24","conditions":"Invasive Breast Carcinoma, Recurrent Breast Carcinoma, Stage III Breast Cancer AJCC v6","enrollment":394},{"nctId":"NCT06295341","phase":"","title":"Short Stature and Psychological Well-being","status":"COMPLETED","sponsor":"Istituto Auxologico Italiano","startDate":"2023-05-10","conditions":"Short Stature, Short; Stature, Psychosocial","enrollment":80},{"nctId":"NCT06135168","phase":"PHASE1","title":"A Clinical Trail to Compare Pharmacokinetics of Two PEG-rhGH Injections With Different Preparations","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2023-10-31","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":60},{"nctId":"NCT06135155","phase":"PHASE1","title":"A Clinical Trial to Compare Pharmacokinetics of Two Different PEG-rhGH Preparations","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2023-11-06","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":48},{"nctId":"NCT06385145","phase":"PHASE1","title":"A Bioavailability Study of Two Different PEG-rhGH Preparations.","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2024-05-08","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":16},{"nctId":"NCT06900335","phase":"","title":"Functional Connectome in Prader-Willi Syndrome: Neuroimaging and AI to Assess Therapeutic Impact","status":"COMPLETED","sponsor":"Corporacion Parc Tauli","startDate":"2025-03-01","conditions":"Prader Willi Syndrome, Hyperphagia, Behavior Disorders","enrollment":101},{"nctId":"NCT06863363","phase":"PHASE4","title":"PEG-rhGH and Semaglutide Combination Therapy in Non-Diabetic Obese Adults","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"","conditions":"Non-diabetic Obesity","enrollment":212},{"nctId":"NCT03554265","phase":"PHASE3","title":"Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy","status":"COMPLETED","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2018-08-06","conditions":"Traumatic Brain Injury, Fatigue, Cognitive Impairment","enrollment":72},{"nctId":"NCT03169764","phase":"PHASE1, PHASE2","title":"QUILT-3.047: NANT Head and Neck Squamous Cell Carcinoma (HNSCC) Vaccine: Combination Immunotherapy in Subjects With HNSCC Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy","status":"WITHDRAWN","sponsor":"ImmunityBio, Inc.","startDate":"2017-12","conditions":"Head and Neck Squamous Cell Carcinoma","enrollment":""},{"nctId":"NCT03169777","phase":"PHASE1, PHASE2","title":"QUILT-3.050: NANT Colorectal Cancer (CRC) Vaccine: Combination Immunotherapy in Subjects With Recurrent or Metastatic CRC","status":"WITHDRAWN","sponsor":"ImmunityBio, Inc.","startDate":"2018-08","conditions":"Colorectal Cancer","enrollment":""},{"nctId":"NCT06840691","phase":"PHASE1","title":"A Bioequivalence Study of Two Different Processes of PEG-rhGH Preparations","status":"NOT_YET_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-05","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":87},{"nctId":"NCT03169738","phase":"PHASE1, PHASE2","title":"QUILT-3.044: NANT Non-small Cell Lung Cancer (NSCLC) Vaccine: Combination Immunotherapy in Subjects With NSCLC Who Have Progressed After Treatment With PD-1/PD-L1 Inhibitors","status":"WITHDRAWN","sponsor":"ImmunityBio, Inc.","startDate":"2018-02","conditions":"Non-small Cell Lung Cancer","enrollment":""},{"nctId":"NCT03197571","phase":"PHASE1, PHASE2","title":"QUILT-3.048: NANT Urothelial Cancer Vaccine: Combination Immunotherapy in Subjects With Urothelial Cancer Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy","status":"WITHDRAWN","sponsor":"ImmunityBio, Inc.","startDate":"2017-12","conditions":"Urothelial Carcinoma","enrollment":""},{"nctId":"NCT06768411","phase":"NA","title":"The Dosage Exploration Study of PEG-rhGH for Treating Short Stature in Prepubertal and Pubertal Children","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital of Wenzhou Medical University","startDate":"2025-01-15","conditions":"Short Stature","enrollment":240},{"nctId":"NCT06722079","phase":"","title":"A Real-world Study of Long-acting Growth Hormone Injection for Turner Syndrome","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2022-11-08","conditions":"Turner Syndrome","enrollment":743},{"nctId":"NCT06331026","phase":"PHASE1","title":"A Bioequivalence Study of Two Different PEG-rhGH Preparations.","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2024-04-09","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":87},{"nctId":"NCT06110910","phase":"","title":"Long-term Efficacy and Safety Evaluation of Growth Hormone in Children in China(CGLS)","status":"RECRUITING","sponsor":"Xiaoping Luo","startDate":"2023-03-01","conditions":"Childhood Short Stature","enrollment":10000},{"nctId":"NCT06354023","phase":"PHASE2","title":"Human Growth Hormone Injections in the Knee Joint to Treat Osteoarthritis","status":"SUSPENDED","sponsor":"John Sledge","startDate":"2025-02-08","conditions":"Osteoarthritis, Knee","enrollment":23},{"nctId":"NCT00684957","phase":"PHASE1, PHASE2","title":"Differential Effects of rhGH vs. rhIGF-1 on Cardiovascular Risk Factors","status":"TERMINATED","sponsor":"Columbia University","startDate":"2008-01","conditions":"Growth Hormone Deficiency","enrollment":5},{"nctId":"NCT00557193","phase":"PHASE3","title":"Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia","status":"COMPLETED","sponsor":"Children's Oncology Group","startDate":"2008-01-15","conditions":"Acute Lymphoblastic Leukemia, Acute Undifferentiated Leukemia, Childhood T Acute Lymphoblastic Leukemia","enrollment":218},{"nctId":"NCT06126354","phase":"PHASE1","title":"Dexamethasone/Pancreatic Clamp P&F","status":"WITHDRAWN","sponsor":"Columbia University","startDate":"2024-07-01","conditions":"Insulin Resistance, Prediabetic State, Non-Alcoholic Fatty Liver Disease","enrollment":""},{"nctId":"NCT00697255","phase":"PHASE2","title":"A Phase 2 Trial to Evaluate if Corifollitropin Alfa (Org 36286), Followed by a Low Daily Dose of hCG or Recombinant FSH Can Induce Monofollicular Growth in Women With WHO Group II Anovulatory Infertility (P05693)","status":"TERMINATED","sponsor":"Organon and Co","startDate":"2007-05-15","conditions":"Ovulation Induction","enrollment":8},{"nctId":"NCT04003207","phase":"PHASE2","title":"Growth Hormone Treatment in Children With Phelan McDermid Syndrome","status":"COMPLETED","sponsor":"Swathi Sethuram","startDate":"2019-09-13","conditions":"Phelan McDermid Syndrome","enrollment":6},{"nctId":"NCT04633057","phase":"PHASE3","title":"A Study to Evaluating the Efficacy and Safety of Recombinant Long-acting Human Growth Hormone (TJ101) in Children With Growth Hormone Deficiency","status":"COMPLETED","sponsor":"TJ Biopharma Co., Ltd.","startDate":"2021-01-25","conditions":"Pediatric Growth Hormone Deficiency","enrollment":168},{"nctId":"NCT05838885","phase":"PHASE2","title":"A Trial of YPEG-rhGH in Children With Short Stature","status":"COMPLETED","sponsor":"Xiamen Amoytop Biotech Co., Ltd.","startDate":"2022-02-15","conditions":"Idiopathic Short Stature, Small for Gestational Age, Turner Syndrome","enrollment":78},{"nctId":"NCT05238831","phase":"EARLY_PHASE1","title":"SMMART Adaptive Clinical Treatment (ACT) Trial","status":"WITHDRAWN","sponsor":"OHSU Knight Cancer Institute","startDate":"2023-01-30","conditions":"Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Ovarian Carcinoma","enrollment":""},{"nctId":"NCT06103513","phase":"PHASE3","title":"Randomized Clinical Trial of Two Different Initial Growth Hormone Doses in Children","status":"UNKNOWN","sponsor":"Northwell Health","startDate":"2023-12-10","conditions":"Growth Disorders, Growth Failure, Growth Hormone Treatment","enrollment":50},{"nctId":"NCT05567731","phase":"NA","title":"Effect of GnRH Agonist Treatment Protocols on Ovarian Reserve","status":"COMPLETED","sponsor":"Tanta University","startDate":"2022-10-15","conditions":"Intracytoplasmic Sperm Injection, GnRH Agonist, Infertility","enrollment":30},{"nctId":"NCT04724343","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes.","status":"COMPLETED","sponsor":"Damascus University","startDate":"2019-12-22","conditions":"In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility","enrollment":50},{"nctId":"NCT04727671","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.","status":"COMPLETED","sponsor":"Damascus University","startDate":"2019-12-22","conditions":"In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility","enrollment":50},{"nctId":"NCT03223025","phase":"PHASE3","title":"Comparing Efficacy and Safety of CinnaGen Biosimilar Growth Hormone (CinnaTropin®) Versus Nordilet in Children With Idiopathic Growth Hormone Deficiency","status":"COMPLETED","sponsor":"Cinnagen","startDate":"2016-03-09","conditions":"Idiopathic Growth Hormone Deficiency","enrollment":30},{"nctId":"NCT00571727","phase":"PHASE2, PHASE3","title":"Long-Term Treatment With rhIGF-1 in GHIS","status":"COMPLETED","sponsor":"Ipsen","startDate":"1991-05-20","conditions":"Growth Hormone Insensitivity Syndrome","enrollment":92},{"nctId":"NCT00673309","phase":"PHASE2, PHASE3","title":"Assessment of Mechanisms of Improved Wound Healing","status":"COMPLETED","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2000-07","conditions":"Burns","enrollment":644},{"nctId":"NCT05602090","phase":"PHASE2, PHASE3","title":"Growth Hormone For Poor Ovarian Reserve Patients in ICSI Trials","status":"UNKNOWN","sponsor":"Beni-Suef University","startDate":"2022-02-01","conditions":"Poor Ovarian Reserve","enrollment":120},{"nctId":"NCT05144035","phase":"PHASE4","title":"A Real World Study of the Effect of Early PEG-rhGH Therapy on Cognitive Development of SGA Infants","status":"RECRUITING","sponsor":"Tongji Hospital","startDate":"2022-04-06","conditions":"Small for Gestational Age Infant, Growth Hormone Treatment, Cognitive Developmental Disorder","enrollment":138},{"nctId":"NCT02719990","phase":"PHASE2","title":"Open-label Extension Study to Evaluate the Safety of Long-term Twice-monthly Administration of Somavaratan in Adult Growth Hormone Deficiency (AGHD)","status":"TERMINATED","sponsor":"Versartis Inc.","startDate":"2016-02-11","conditions":"Adult Growth Hormone Deficiency (AGHD)","enrollment":36},{"nctId":"NCT00572156","phase":"PHASE2","title":"rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency","status":"TERMINATED","sponsor":"Ipsen","startDate":"2007-12","conditions":"Insulin-like Growth Factor-1 Deficiency","enrollment":106},{"nctId":"NCT05790447","phase":"PHASE2","title":"Thymalfasin-based PRaG Mode for Advanced Refractory Solid Tumors","status":"UNKNOWN","sponsor":"Second Affiliated Hospital of Soochow University","startDate":"2023-04-01","conditions":"Advanced Solid Tumor, Refractory Tumor","enrollment":60},{"nctId":"NCT05353192","phase":"PHASE4","title":"A Study to Evaluate the Efficacy and Safety of Recombinant Human Growth Hormone in Children With Achondroplasia","status":"UNKNOWN","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2022-09-23","conditions":"Achondroplasia","enrollment":38},{"nctId":"NCT02339090","phase":"PHASE3","title":"Long-Acting Growth Hormone in Children Compared to Daily rhGH","status":"COMPLETED","sponsor":"Versartis Inc.","startDate":"2015-08-26","conditions":"Growth Disorders","enrollment":138},{"nctId":"NCT02947438","phase":"PHASE3","title":"Biosimilar Erythropoietin in Anaemia Treatment (Maintenance Phase Study)","status":"COMPLETED","sponsor":"Shenyang Sunshine Pharmaceutical Co., LTD.","startDate":"2015-12","conditions":"Renal Anemia","enrollment":207},{"nctId":"NCT05105685","phase":"PHASE1, PHASE2","title":"Effectiveness of Recombinant Human Growth Hormone Therapy for Children With PMS","status":"COMPLETED","sponsor":"Affiliated Hospital of Jiangnan University","startDate":"2020-06-14","conditions":"Phelan-McDermid Syndrome, Growth Hormone Treatment","enrollment":6},{"nctId":"NCT02973061","phase":"","title":"The Impact of the Use of Recombinant Human Growth Hormone on ADHD Characteristics in Children and Adolescents","status":"UNKNOWN","sponsor":"Assaf-Harofeh Medical Center","startDate":"2015-01","conditions":"Growth Hormone Deficiency, Attention Deficit Disorder, Idiopathic Short Stature","enrollment":100},{"nctId":"NCT02526420","phase":"PHASE2","title":"Versartis International Trial in Adults With Long-Acting Growth Hormone","status":"COMPLETED","sponsor":"Versartis Inc.","startDate":"2015-07","conditions":"Adult Growth Hormone Deficiency","enrollment":36},{"nctId":"NCT02413138","phase":"PHASE2, PHASE3","title":"Versartis Trial in Pre-pubertal Japanese Children With Growth Hormone Deficiency (GHD) to Assess Long-Acting Growth Hormone (Somavaratan, VRS-317)","status":"TERMINATED","sponsor":"Versartis Inc.","startDate":"2015-08-08","conditions":"Pediatric Growth Hormone Deficiency, Growth Disorders","enrollment":41},{"nctId":"NCT01614171","phase":"NA","title":"Growth Hormone for Osteoporosis Pseudoglioma Syndrome","status":"WITHDRAWN","sponsor":"University of Maryland, Baltimore","startDate":"2013-12","conditions":"Osteoporosis Pseudoglioma Syndrome","enrollment":""},{"nctId":"NCT02205450","phase":"","title":"Growth Hormone in Children Under 2 Years With Prader-Willi in Hospital of Sabadell","status":"COMPLETED","sponsor":"Corporacion Parc Tauli","startDate":"2014-09","conditions":"Prader-Willi Syndrome","enrollment":16},{"nctId":"NCT02410343","phase":"PHASE3","title":"Study of TV-1106 in Growth Hormone-Deficient Adults","status":"TERMINATED","sponsor":"Teva Branded Pharmaceutical Products R&D, Inc.","startDate":"2015-04-30","conditions":"Growth Hormone Deficiency","enrollment":14},{"nctId":"NCT01811576","phase":"PHASE2","title":"Safety, Tolerability and Efficacy of Weekly TV-1106 in Adults With Growth Hormone Deficiency","status":"COMPLETED","sponsor":"Teva Branded Pharmaceutical Products R&D, Inc.","startDate":"2013-03-31","conditions":"Growth Hormone Deficiency","enrollment":52},{"nctId":"NCT02092077","phase":"PHASE2","title":"A Phase 2, Safety and Dose-Finding Study in Treatment-Naive, Pre-Pubertal, Growth Hormone-Deficient Children","status":"TERMINATED","sponsor":"Teva Pharmaceutical Industries, Ltd.","startDate":"2014-04-30","conditions":"Growth Hormone-Deficiency","enrollment":65},{"nctId":"NCT01169103","phase":"PHASE2","title":"Effect of Recombinant Human Growth Hormone (rhGH) on Abdominal Fat and Cardiovascular Risk in Obese Girls","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2010-03","conditions":"Obesity","enrollment":22},{"nctId":"NCT00006143","phase":"NA","title":"Growth Hormone Treatment of Children With HIV-Associated Growth Failure","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":102},{"nctId":"NCT05089344","phase":"NA","title":"Growth Hormone Pretreatment in Poseidon Type IV Undergoing ICSI Using Minimal Induction Protocol: A Randomized Controlled Trial","status":"UNKNOWN","sponsor":"Ain Shams Maternity Hospital","startDate":"2021-10-09","conditions":"Poor Response to Ovulation Induction Poseidon Type IV","enrollment":132},{"nctId":"NCT05070234","phase":"","title":"Genetic Diagnosis and Human Growth Hormone Treatment in Small for Gestational Age Children With Short Stature","status":"UNKNOWN","sponsor":"Chunxiu Gong","startDate":"2021-10-11","conditions":"Small for Gestational Age Infant, Silver-Russell Syndrome, Genetic Diseases, Inborn","enrollment":150},{"nctId":"NCT03874013","phase":"PHASE3","title":"Safety and Efficacy Study of MOD-4023 to Treat Children With Growth Hormone Deficiency","status":"COMPLETED","sponsor":"OPKO Health, Inc.","startDate":"2017-12-07","conditions":"Growth Hormone Deficiency","enrollment":44},{"nctId":"NCT01220128","phase":"PHASE2","title":"Evaluation of an Anti-cancer Immunotherapy Combined With Standard Neoadjuvant Treatment in Patients With WT1-positive Primary Invasive Breast Cancer","status":"TERMINATED","sponsor":"GlaxoSmithKline","startDate":"2011-04-11","conditions":"Neoplasms, Breast","enrollment":66},{"nctId":"NCT02522975","phase":"PHASE4","title":"Biosimilar Erythropoietin in Anaemia Treatment (Correction Phase Study)","status":"TERMINATED","sponsor":"Shenyang Sunshine Pharmaceutical Co., LTD.","startDate":"2015-08","conditions":"Renal Anaemia","enrollment":16},{"nctId":"NCT04588844","phase":"NA","title":"Effect of Growth Hormone Injection on the IVF/ICSI Outcome of Patients With Poor Ovarian Reserve.","status":"UNKNOWN","sponsor":"Shandong University","startDate":"2020-12-01","conditions":"Poor Ovarian Reserve","enrollment":200},{"nctId":"NCT04532554","phase":"PHASE4","title":"Growth Hormone in Obese Cases With Covid-19","status":"WITHDRAWN","sponsor":"ClinAmygate","startDate":"2020-10-26","conditions":"Covid19","enrollment":""},{"nctId":"NCT00182091","phase":"NA","title":"Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2004-08","conditions":"Acromegaly, Growth Hormone Deficiency, Pituitary Disease","enrollment":75},{"nctId":"NCT00283595","phase":"PHASE2","title":"Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2006-01","conditions":"Anorexia Nervosa, Osteopenia, Osteoporosis","enrollment":21},{"nctId":"NCT03309891","phase":"PHASE2","title":"Dose Finding Study of GX-H9 in Paeditaric Patients With Growth Hormone Deficiency","status":"COMPLETED","sponsor":"Genexine, Inc.","startDate":"2016-01-18","conditions":"Growth Hormone Deficiency","enrollment":56},{"nctId":"NCT00720109","phase":"PHASE2, PHASE3","title":"Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2008-07-14","conditions":"Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1, Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1","enrollment":63},{"nctId":"NCT02179255","phase":"PHASE1, PHASE2","title":"Human Growth Hormone Pre-treatment for 6 Weeks Prior to Ovulation Induction for IVF","status":"UNKNOWN","sponsor":"Center for Human Reproduction","startDate":"2014-08-01","conditions":"Female Infertility Due to Diminished Ovarian Reserve","enrollment":30},{"nctId":"NCT04042428","phase":"PHASE1","title":"Generation of Biological Samples Positive to Somatropin for Anti-doping Control","status":"COMPLETED","sponsor":"Parc de Salut Mar","startDate":"2019-10-25","conditions":"Healthy Volunteers","enrollment":6},{"nctId":"NCT02420353","phase":"PHASE2","title":"Evaluation of rGH Therapy to Prevent Muscle Atrophy in Patients With ACL Tears","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2015-05","conditions":"Rupture of Anterior Cruciate Ligament","enrollment":20},{"nctId":"NCT00675714","phase":"PHASE2, PHASE3","title":"Assessment of the Treatment of Severely Burned With Anabolic Agents on Clinical Outcomes, Recovery and Rehabilitation","status":"TERMINATED","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2004-01","conditions":"Burns","enrollment":1126},{"nctId":"NCT00766038","phase":"PHASE2","title":"Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury.","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2008-09","conditions":"Traumatic Brain Injury","enrollment":63},{"nctId":"NCT02770157","phase":"PHASE3","title":"Efficacy and Safety of DA-3002 in Short Children Borns SGA.","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2016-02-26","conditions":"Infant, Small for Gestational Age","enrollment":75},{"nctId":"NCT03717168","phase":"PHASE2","title":"Effects of Growth Hormone on Difficult Ventilator Weaning Patients","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2018-03-01","conditions":"Mechanical Ventilation Complication","enrollment":60},{"nctId":"NCT00915954","phase":"NA","title":"Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)","status":"COMPLETED","sponsor":"Cedars-Sinai Medical Center","startDate":"2008-12","conditions":"Acromegaly, Type 2 Diabetes Mellitus","enrollment":28},{"nctId":"NCT03759301","phase":"PHASE4","title":"Efficacy of Growth Hormone Supplementation With Gonadotrophins in IVF/ICSI for Poor Responders","status":"COMPLETED","sponsor":"ClinAmygate","startDate":"2018-12-20","conditions":"Infertility, Female","enrollment":156},{"nctId":"NCT01088412","phase":"","title":"Observational Study of Somatropin Treatment in Children","status":"COMPLETED","sponsor":"Eli Lilly and Company","startDate":"1999-04","conditions":"Growth Hormone (GH) Deficiency, Short Stature Homeobox Containing Gene (SHOX) Deficiency, SHOX Deficiency-related Disorder","enrollment":22845}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2586,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Somatotropin","Genotropin(R)","HGH","Saizen","r-hGH"],"phase":"marketed","status":"active","brandName":"Recombinant human Growth Hormone","genericName":"Recombinant human Growth Hormone","companyName":"University of Pennsylvania","companyId":"university-of-pennsylvania","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Recombinant human growth hormone binds to growth hormone receptors on target cells to stimulate growth, metabolism, and protein synthesis. Used for Growth hormone deficiency in children, Growth hormone deficiency in adults, Short stature due to growth hormone insufficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}