{"id":"rec-hcg","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Abdominal discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"rec-hCG is a recombinant form of human chorionic gonadotropin, a glycoprotein hormone that acts on luteinizing hormone receptors in the testes and ovaries. In males, it stimulates testosterone production and spermatogenesis; in females, it supports corpus luteum function and progesterone production during the luteal phase. It is used clinically to induce ovulation, support luteal phase function, and treat hypogonadism.","oneSentence":"Recombinant human chorionic gonadotropin (rec-hCG) mimics the natural hormone hCG to stimulate gonadal hormone production and support reproductive function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:31:25.176Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction of ovulation in anovulatory women"},{"name":"Support of luteal phase in assisted reproductive technology (ART)"},{"name":"Treatment of hypogonadism in males"}]},"trialDetails":[{"nctId":"NCT07121751","phase":"PHASE4","title":"Optimal Stimulation of Hypo-responders Undergoing in Vitro Fertilization (IVF)","status":"NOT_YET_RECRUITING","sponsor":"Dunamenti REK Istenhegyi IVF Center","startDate":"2025-09-01","conditions":"Hypo-responder, Infertility (IVF Patients), OVARIAN STIMULATION","enrollment":150},{"nctId":"NCT05330130","phase":"PHASE1","title":"Impact of FSH Dosage During Ovarian Stimulation for IVF/ICSI in Granulosa Cells","status":"COMPLETED","sponsor":"ART Fertility Clinics LLC","startDate":"2023-07-05","conditions":"Ovarian Function Insufficiency, Fertility Issues, Infertility,Female","enrollment":6},{"nctId":"NCT00702234","phase":"","title":"Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05714 (Care Program)(P05715)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2007-02-15","conditions":"Pregnancy, Neonates","enrollment":268},{"nctId":"NCT00696878","phase":"PHASE3","title":"Corifollitropin Alfa in Participants Undergoing Repeated Controlled Ovarian Stimulation (COS) Cycles Using a Multiple Dose Gonadatropin Releasing Hormone (GnRH) Antagonist Protocol (Study 38825)(P05714)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-09-26","conditions":"In Vitro Fertilization","enrollment":682},{"nctId":"NCT04189133","phase":"PHASE2","title":"Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men","status":"UNKNOWN","sponsor":"Azienda Ospedaliero-Universitaria di Modena","startDate":"2022-01-19","conditions":"Acquired Hypogonadotropic Hypogonadism","enrollment":32},{"nctId":"NCT02349945","phase":"PHASE2, PHASE3","title":"FSH Receptor Polymorphism p.N680S and Efficacy of FSH Therapy","status":"COMPLETED","sponsor":"Azienda USL Modena","startDate":"2011-01","conditions":"Male Infertility","enrollment":88},{"nctId":"NCT00953628","phase":"PHASE4","title":"Endometrial Advancement After Rec or u-HCG Triggering","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2005-08","conditions":"Infertility","enrollment":130},{"nctId":"NCT00870025","phase":"PHASE4","title":"Human Chorionic Gonadotropin (hCG) Priming Prior to Controlled Ovarian Hyperstimulation (COH) in Poor Responder In Vitro Fertilization (IVF) Patients","status":"COMPLETED","sponsor":"IVI Madrid","startDate":"2008-10","conditions":"Ovarian Response","enrollment":60},{"nctId":"NCT02046655","phase":"PHASE4","title":"Corifollitropin Alfa Compared to Daily rFSH in Poor Responders Undergoing ICSI","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2011-01","conditions":"Subfertility","enrollment":80},{"nctId":"NCT00866008","phase":"PHASE4","title":"A Study of the Effects of a Novel Ovarian Stimulation Regimen on Embryo Aneuploidy Rates in In Vitro Fertilization (IVF)","status":"TERMINATED","sponsor":"Bart CJM Fauser","startDate":"2008-10","conditions":"In Vitro Fertilization","enrollment":34},{"nctId":"NCT01662180","phase":"","title":"Predicting Ovarian Response in Artificial Insemination With Low Stimulation","status":"UNKNOWN","sponsor":"Isala","startDate":"2012-12","conditions":"Subfertility","enrollment":510},{"nctId":"NCT01390207","phase":"PHASE2, PHASE3","title":"Earlier Triggering in Rec-FSH/GnRH Antagonist Cycles","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2010-01","conditions":"hCG","enrollment":100},{"nctId":"NCT00954811","phase":"PHASE4","title":"Luteal Supplementation With Rec-LH After GnRH-agonist Triggering in In Vitro (IVF)","status":"UNKNOWN","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2005-09","conditions":"Pregnancy, Pregnancy Loss","enrollment":40},{"nctId":"NCT00954265","phase":"PHASE3","title":"Pregnancy Rates in IVF After Ovulation Triggering With Recombinant or Urinary Human Chorionic Gonadotrophin (HCG)","status":"UNKNOWN","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2005-08","conditions":"Embryonic Development, Pregnancy, VEGF","enrollment":130}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"(rec)hCG","genericName":"(rec)hCG","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Biologic","firstApprovalDate":"","aiSummary":"Recombinant human chorionic gonadotropin (rec)hCG is used in fertility treatments, specifically in IVF patients, to stimulate embryonic development and pregnancy. It is often used as an alternative to urinary HCG, and can be administered in combination with recombinant FSH and LH.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}