{"id":"rauwolfia-alkaloids","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Drowsiness"},{"rate":"5-10%","effect":"Dry mouth"},{"rate":"5-10%","effect":"Postural hypotension"}]},"_chembl":{"chemblId":"CHEMBL3559672","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This is achieved through the inhibition of the enzyme dopamine beta-hydroxylase, which is responsible for converting dopamine to norepinephrine. By reducing norepinephrine levels, rauwolfia alkaloids lead to decreased heart rate, blood pressure, and cardiac workload.","oneSentence":"Rauwolfia alkaloids decrease sympathetic nervous system activity by inhibiting the release of norepinephrine.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:31:15.955Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT00000484","phase":"PHASE3","title":"Treatment of Hypertension","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"1966-04","conditions":"Cardiovascular Diseases, Heart Diseases, Hypertension","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1086,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Rauwolfia alkaloids","genericName":"Rauwolfia alkaloids","companyName":"National Heart, Lung, and Blood Institute (NHLBI)","companyId":"national-heart-lung-and-blood-institute-nhlbi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rauwolfia alkaloids are used to treat cardiovascular diseases, including hypertension, and have been studied in combination with chlorothiazide. They work by antagonizing the adrenergic receptor alpha, a mechanism that is classified as an antagonist.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}