{"id":"rapidly-cycled-haart","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Lipodystrophy"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Peripheral neuropathy"}]},"_chembl":{"chemblId":"CHEMBL1200485","moleculeType":"Small molecule","molecularWeight":"637.04"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This approach involves alternating between different combinations of antiretroviral drugs (typically nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors) on a scheduled basis rather than using a fixed combination continuously. The rationale is that rapid cycling may prevent the emergence of drug-resistant viral strains by not allowing any single resistant mutant population to become dominant, while maintaining viral suppression.","oneSentence":"Rapidly Cycled HAART is a highly active antiretroviral therapy regimen that uses rapid rotation or cycling of different antiretroviral drug classes to suppress HIV replication and potentially reduce resistance development.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:36:54.416Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV-1 infection"}]},"trialDetails":[{"nctId":"NCT00128908","phase":"PHASE4","title":"Sequential HIV Therapy in Treatment Resistant HIV-1 Infected Patients","status":"TERMINATED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2005-09","conditions":"HIV Infections","enrollment":3}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Rapidly Cycled HAART","genericName":"Rapidly Cycled HAART","companyName":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","companyId":"academisch-medisch-centrum-universiteit-van-amsterdam-amc-uva","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rapidly Cycled HAART is a highly active antiretroviral therapy regimen that uses rapid rotation or cycling of different antiretroviral drug classes to suppress HIV replication and potentially reduce resistance development. Used for HIV-1 infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}