{"id":"ramucirumab-imc-1211b-dp","brandName":"Ramucirumab (IMC-1211B) DP","genericName":"Ramucirumab (IMC-1211B) DP","companyId":"eli-lilly","companyName":"Eli Lilly and Company","phase":"phase_3","status":"active","modality":"Biologic","aliases":["LY3009806","IMC-1211B"],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Ramucirumab is a monoclonal antibody developed by Eli Lilly for the treatment of metastatic gastric adenocarcinoma. It targets VEGFR-2 to inhibit angiogenesis. Despite no FDA label, it has completed a Phase 3 trial showing promise in combination with paclitaxel.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Ramucirumab binds to VEGFR2 on endothelial cells, preventing ligand-induced activation and downstream signaling that promotes new blood vessel formation. By inhibiting angiogenesis, the drug reduces blood supply to tumors, limiting their growth and metastatic potential. It is often used in combination with chemotherapy to enhance anti-tumor efficacy.","oneSentence":"Ramucirumab is a monoclonal antibody that blocks vascular endothelial growth factor receptor 2 (VEGFR2) to inhibit tumor angiogenesis and vascular growth.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"40-50","effect":"Hypertension"},{"rate":"20-30","effect":"Diarrhea"},{"rate":"15-25","effect":"Fatigue"},{"rate":"15-20","effect":"Nausea"},{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Bleeding events"},{"rate":"5-10","effect":"Proteinuria"},{"rate":"5-10","effect":"Infusion-related reactions"}]},"trials":[],"indications":{"approved":[{"name":"Metastatic non-small cell lung cancer (in combination with docetaxel)"},{"name":"Gastric or gastroesophageal junction adenocarcinoma (in combination with chemotherapy)"},{"name":"Metastatic colorectal cancer (in combination with FOLFIRI)"},{"name":"Hepatocellular carcinoma (in combination with atezolizumab)"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}