{"id":"ramelteon-rozeremr","safety":{"commonSideEffects":[{"rate":"3-5%","effect":"Dizziness"},{"rate":"2-4%","effect":"Fatigue"},{"rate":"2-3%","effect":"Headache"},{"rate":"1-2%","effect":"Nausea"},{"rate":"1-2%","effect":"Somnolence"}]},"_chembl":{"chemblId":"CHEMBL1218","moleculeType":"Small molecule","molecularWeight":"259.35"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ramelteon selectively targets melatonin receptors MT1 and MT2 located in the suprachiasmatic nucleus, the brain's master circadian clock. By activating these receptors, it helps synchronize the sleep-wake cycle and promotes sleep initiation without the sedative properties of traditional hypnotics. This mechanism makes it particularly useful for circadian rhythm sleep disorders.","oneSentence":"Ramelteon is a melatonin receptor agonist that binds to MT1 and MT2 receptors in the brain to promote sleep onset and maintain circadian rhythm.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:03:45.868Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia, particularly sleep-onset insomnia"}]},"trialDetails":[{"nctId":"NCT05414864","phase":"PHASE4","title":"Insomnia Prevalence and Treatment Impact on Systemic Hypertension","status":"TERMINATED","sponsor":"University of Sao Paulo","startDate":"2022-05-01","conditions":"Insomnia, Hypertension","enrollment":5}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ramelteon (RozeremR)","genericName":"Ramelteon (RozeremR)","companyName":"University of Sao Paulo","companyId":"university-of-sao-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ramelteon is a melatonin receptor agonist that binds to MT1 and MT2 receptors in the brain to promote sleep onset and maintain circadian rhythm. Used for Insomnia, particularly sleep-onset insomnia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}