{"id":"ragweed-12-amb-a-1-u","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (erythema, swelling, pruritus)"},{"rate":null,"effect":"Systemic allergic reactions"},{"rate":null,"effect":"Anaphylaxis (rare)"}]},"_chembl":{"chemblId":"CHEMBL414723","moleculeType":"Small molecule","molecularWeight":"1669.88"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is an allergen extract preparation containing ragweed (Ambrosia) pollen antigens used in immunotherapy. It works by gradually inducing immune tolerance to ragweed allergens, reducing allergic responses upon natural exposure. The standardized potency (1-U) allows for controlled dosing in allergy treatment protocols.","oneSentence":"Ragweed pollen extract allergen immunotherapy that desensitizes the immune system to ragweed allergens through repeated controlled exposure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:03:38.156Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ragweed pollen allergy (allergic rhinitis and/or allergic asthma)"},{"name":"Immunotherapy desensitization to ragweed allergens"}]},"trialDetails":[{"nctId":"NCT05119751","phase":"PHASE4","title":"Vestibular Versus Sublingual Route of AIT Tablets","status":"COMPLETED","sponsor":"Clinique Spécialisée en Allergies de la Capitale","startDate":"2021-10-25","conditions":"Hypersensitivity","enrollment":172},{"nctId":"NCT02478398","phase":"PHASE3","title":"Efficacy and Safety Study of RAGWITEK™ (MK-3641) in Children With Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (MK-3641-008)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2015-07-20","conditions":"Rhinitis, Allergic, Seasonal","enrollment":1025},{"nctId":"NCT01469182","phase":"PHASE3","title":"A Study of Ragweed (Ambrosia Artemisiifolia) Allergy Immunotherapy Tablet in Adults With Ragweed Allergies (P05751)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2011-11","conditions":"Allergy","enrollment":914},{"nctId":"NCT00978029","phase":"PHASE2","title":"Safety Study of Ragweed Allergy Immunotherapy Tablet in Subjects 50 Years of Age and Older (Study P06081)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2009-11","conditions":"Rhinoconjunctivitis, Rhinitis, Conjunctivitis","enrollment":203},{"nctId":"NCT00783198","phase":"PHASE2, PHASE3","title":"Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05233)(COMPLETED)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2009-09","conditions":"Rhinitis; Allergic, With Asthma, Conjunctivitis","enrollment":565},{"nctId":"NCT02256553","phase":"PHASE4","title":"Safety Study of MK-3641 and MK-7243 Co-administered in Adult Participants With Ragweed and Grass Pollen Induced Allergic Rhinitis (P08607, MK-3641-006)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2014-10","conditions":"Rhinitis, Allergic, Seasonal","enrollment":102},{"nctId":"NCT00770315","phase":"PHASE2, PHASE3","title":"Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet (SCH 39641) in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05234)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2009-09","conditions":"Rhinitis, Allergic, Conjunctivitis","enrollment":784}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["RAGWITEK"],"phase":"marketed","status":"active","brandName":"RAGWEED 12 AMB A 1-U","genericName":"RAGWEED 12 AMB A 1-U","companyName":"Clinique Spécialisée en Allergies de la Capitale","companyId":"clinique-sp-cialis-e-en-allergies-de-la-capitale","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ragweed pollen extract allergen immunotherapy that desensitizes the immune system to ragweed allergens through repeated controlled exposure. Used for Ragweed pollen allergy (allergic rhinitis and/or allergic asthma), Immunotherapy desensitization to ragweed allergens.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}