{"id":"radiopaque-implanon","safety":{"commonSideEffects":[{"rate":null,"effect":"Irregular bleeding/amenorrhea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Insertion site pain/infection"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Implanon is a single flexible plastic rod measuring 3 cm in length that is inserted subdermally in the upper arm. It releases etonogestrel, a synthetic progestin, at a controlled rate over three years. The progestin works by inhibiting the LH surge necessary for ovulation, thickening cervical mucus to impede sperm transport, and altering the endometrium. The 'radiopaque' formulation contains barium sulfate to make the implant visible on X-rays for easier localization during removal.","oneSentence":"Radiopaque Implanon is a subdermal contraceptive implant containing etonogestrel that provides long-acting reversible contraception by suppressing ovulation through progestin delivery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:52:14.022Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Long-acting reversible contraception in women of reproductive age"}]},"trialDetails":[{"nctId":"NCT04626596","phase":"PHASE3","title":"A Study to Assess Contraceptive Efficacy and Safety of Etonogestrel (ENG) Implant Beyond 3 Years of Use (MK-8415-060)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2020-11-19","conditions":"Contraception","enrollment":498},{"nctId":"NCT04814927","phase":"PHASE4","title":"Impact of Contraceptives on Cervico-Vaginal Mucosa","status":"COMPLETED","sponsor":"Eastern Virginia Medical School","startDate":"2021-03-01","conditions":"Mucosal Inflammation, Contraceptive; Complications, Intrauterine","enrollment":112},{"nctId":"NCT00620464","phase":"PHASE3","title":"A Bioequivalence Study of IMPLANON and Radiopaque IMPLANON (34528)(P05720)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2005-05","conditions":"Contraception","enrollment":108},{"nctId":"NCT03656289","phase":"PHASE1","title":"Antepartum Etonogestrel Contraceptive Implant Insertion at Term","status":"WITHDRAWN","sponsor":"University of Colorado, Denver","startDate":"2019-01-01","conditions":"Contraception","enrollment":""},{"nctId":"NCT02657148","phase":"","title":"Immediate Postpartum Nexplanon Placement in Opioid Dependent Women","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2016-05","conditions":"Opiate Addiction, Pregnancy, Contraceptive Behavior","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Radiopaque Implanon","genericName":"Radiopaque Implanon","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Radiopaque Implanon is a subdermal contraceptive implant containing etonogestrel that provides long-acting reversible contraception by suppressing ovulation through progestin delivery. Used for Long-acting reversible contraception in women of reproductive age.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}