{"id":"radiopaque-etonogestrel-implant","safety":{"commonSideEffects":[{"rate":null,"effect":"Irregular bleeding or amenorrhea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Insertion site pain or infection"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Etonogestrel is a synthetic progestin that suppresses the luteinizing hormone (LH) surge necessary for ovulation and alters cervical mucus consistency to impede sperm transport. The radiopaque formulation incorporates barium sulfate or similar contrast agents to enhance visibility on X-rays and other imaging modalities, improving clinical localization and removal if needed.","oneSentence":"A subdermal contraceptive implant that releases etonogestrel (a progestin) to prevent ovulation and thicken cervical mucus, with added radiopaque material for improved visibility on imaging.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:52:14.038Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception in women of reproductive age"}]},"trialDetails":[{"nctId":"NCT04626596","phase":"PHASE3","title":"A Study to Assess Contraceptive Efficacy and Safety of Etonogestrel (ENG) Implant Beyond 3 Years of Use (MK-8415-060)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2020-11-19","conditions":"Contraception","enrollment":498},{"nctId":"NCT05156658","phase":"PHASE4","title":"Pharmacokinetic Interactions of ENG Subdermal Implants with Long-Acting Cabotegravir (CAB-LA) and LA Rilpivirine (RPV-LA) (CARLA)","status":"WITHDRAWN","sponsor":"Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections","startDate":"2024-01-01","conditions":"HIV-1-infection","enrollment":""},{"nctId":"NCT04814927","phase":"PHASE4","title":"Impact of Contraceptives on Cervico-Vaginal Mucosa","status":"COMPLETED","sponsor":"Eastern Virginia Medical School","startDate":"2021-03-01","conditions":"Mucosal Inflammation, Contraceptive; Complications, Intrauterine","enrollment":112},{"nctId":"NCT00620035","phase":"PHASE3","title":"A Multicenter Trial to Evaluate the Insertion Characteristics of the Radiopaque Etonogestrel Implant Using a Next Generation Applicator (34530)(P05702)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2007-03","conditions":"Contraception","enrollment":301},{"nctId":"NCT00620464","phase":"PHASE3","title":"A Bioequivalence Study of IMPLANON and Radiopaque IMPLANON (34528)(P05720)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2005-05","conditions":"Contraception","enrollment":108},{"nctId":"NCT03656289","phase":"PHASE1","title":"Antepartum Etonogestrel Contraceptive Implant Insertion at Term","status":"WITHDRAWN","sponsor":"University of Colorado, Denver","startDate":"2019-01-01","conditions":"Contraception","enrollment":""},{"nctId":"NCT02657148","phase":"","title":"Immediate Postpartum Nexplanon Placement in Opioid Dependent Women","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2016-05","conditions":"Opiate Addiction, Pregnancy, Contraceptive Behavior","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["SCH 900415"],"phase":"phase_3","status":"active","brandName":"Radiopaque Etonogestrel Implant","genericName":"Radiopaque Etonogestrel Implant","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A subdermal contraceptive implant that releases etonogestrel (a progestin) to prevent ovulation and thicken cervical mucus, with added radiopaque material for improved visibility on imaging. Used for Contraception in women of reproductive age.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}