{"id":"radiesse-xeomin-belotero","safety":{"commonSideEffects":[{"rate":"10-30%","effect":"Injection site pain, swelling, or bruising"},{"rate":"5-15%","effect":"Erythema or redness at injection site"},{"rate":"5-10%","effect":"Headache (Xeomin)"},{"rate":"1-5%","effect":"Temporary muscle weakness or asymmetry (Xeomin)"},{"rate":"<1-5%","effect":"Nodule formation (fillers)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Radiesse is a calcium hydroxylapatite filler that provides immediate volume and stimulates collagen production. Xeomin is a purified botulinum toxin type A that blocks acetylcholine release at the neuromuscular junction to relax facial muscles and reduce dynamic wrinkles. Belotero is a hyaluronic acid filler that integrates into dermal tissue to restore volume and hydration.","oneSentence":"These are injectable dermal fillers and botulinum toxin products that restore facial volume, smooth wrinkles, and enhance facial contours through different mechanisms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:03:37.585Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Facial wrinkles and folds (dynamic and static)"},{"name":"Facial volume loss and contouring"},{"name":"Lip augmentation and enhancement"}]},"trialDetails":[{"nctId":"NCT05039723","phase":"PHASE4","title":"Xeomin, Radiesse, and Belotero Facial/Neck Rejuvenational","status":"COMPLETED","sponsor":"Main Line Center for Laser Surgery","startDate":"2021-09-01","conditions":"Photoaging","enrollment":22},{"nctId":"NCT04102670","phase":"NA","title":"Combination Therapy for Rejuvenation of the Lower Face and Neck","status":"UNKNOWN","sponsor":"Nashville Centre for Laser and Facial Surgery","startDate":"2019-10-01","conditions":"Laxity; Skin","enrollment":20},{"nctId":"NCT02444169","phase":"","title":"Retrospective Evaluation of Combination Treatment With the Ulthera System","status":"COMPLETED","sponsor":"Ulthera, Inc","startDate":"2015-04","conditions":"Skin Laxity","enrollment":101}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Radiesse, Xeomin, Belotero","genericName":"Radiesse, Xeomin, Belotero","companyName":"Main Line Center for Laser Surgery","companyId":"main-line-center-for-laser-surgery","modality":"Small molecule","firstApprovalDate":"","aiSummary":"These are injectable dermal fillers and botulinum toxin products that restore facial volume, smooth wrinkles, and enhance facial contours through different mechanisms. Used for Facial wrinkles and folds (dynamic and static), Facial volume loss and contouring, Lip augmentation and enhancement.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}