{"id":"racecadotril-plus-ors","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2103772","moleculeType":"Small molecule","molecularWeight":"385.49"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Racecadotril is an enkephalinase inhibitor that prevents the breakdown of enkephalins, endogenous opioid peptides that reduce intestinal fluid secretion and chloride transport. When combined with oral rehydration solution (ORS), it addresses both the underlying cause of diarrhea and the symptomatic fluid/electrolyte loss. This combination approach is particularly effective in acute infectious diarrhea, especially in children.","oneSentence":"Racecadotril inhibits enkephalinase to reduce intestinal fluid secretion, while ORS provides oral rehydration therapy to replace lost electrolytes and fluids.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:31:06.365Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute diarrhea in children"},{"name":"Infectious diarrhea"}]},"trialDetails":[{"nctId":"NCT06529497","phase":"PHASE1, PHASE2","title":"Racecadotril Versus Standard Treatment in Decreasing the Duration of Acute Diarrhoea in Children","status":"NOT_YET_RECRUITING","sponsor":"Liaquat National Hospital & Medical College","startDate":"2024-08-02","conditions":"Diarrhoea","enrollment":260},{"nctId":"NCT03473561","phase":"PHASE3","title":"Study to Evaluate the Efficacy and Safety of Racecadotril in Children Aged 3 to 60 Months Suffering From Acute Diarrhea","status":"COMPLETED","sponsor":"Abbott","startDate":"2018-08-25","conditions":"Diarrhea, Infantile","enrollment":31},{"nctId":"NCT05216822","phase":"PHASE1","title":"Anti-Secretory Drug in Treatment of Acute Watery Diarrhea","status":"COMPLETED","sponsor":"Assiut University","startDate":"2018-06-01","conditions":"Acute Watery Diarrhea","enrollment":50},{"nctId":"NCT03005821","phase":"NA","title":"Chinese Pediatric Massage on Children With Acute Diarrhea: a Randomized Sham Massage Controlled Trial","status":"COMPLETED","sponsor":"Guangzhou University of Traditional Chinese Medicine","startDate":"2017-01","conditions":"Diarrhea","enrollment":84},{"nctId":"NCT03463512","phase":"PHASE3","title":"Controlled Study to Evaluate the Efficacy and Safety of Racecadotril in Infants, Children and Adolescents With Acute Diarrhea","status":"COMPLETED","sponsor":"Abbott","startDate":"2018-03-29","conditions":"Diarrhea","enrollment":124},{"nctId":"NCT01153854","phase":"PHASE3","title":"Safety, Efficacy and Cost-effectiveness of Racecadotril in Children With Acute Diarrhea in Mexico","status":"COMPLETED","sponsor":"National Institute of Pediatrics, Mexico","startDate":"2007-01","conditions":"Diarrhea","enrollment":454}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Racecadotril plus ORS","genericName":"Racecadotril plus ORS","companyName":"Abbott","companyId":"abbott","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Racecadotril is a small molecule neprilysin inhibitor used to treat various forms of diarrhea, including infantile and acute watery diarrhea. It is typically administered in combination with Oral Rehydration Solution (ORS) for treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}