{"id":"r-mifentamil-ketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Dissociative effects"},{"rate":null,"effect":"Emergence reactions"}]},"_chembl":{"chemblId":"CHEMBL742","moleculeType":"Small molecule","molecularWeight":"237.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Remifentanil is a potent synthetic opioid agonist that binds mu-opioid receptors to produce analgesia and sedation with rapid onset and offset due to ester metabolism. Ketamine is a dissociative anesthetic that antagonizes NMDA glutamate receptors, producing anesthesia, analgesia, and dissociation. The combination provides synergistic anesthetic and analgesic effects suitable for procedural sedation and induction.","oneSentence":"Remifentanil and ketamine together provide rapid-onset anesthesia and analgesia by combining opioid mu-receptor agonism with NMDA receptor antagonism.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:03:32.109Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Procedural sedation and anesthesia"},{"name":"Induction of general anesthesia"}]},"trialDetails":[{"nctId":"NCT01560390","phase":"PHASE4","title":"Use of Ketamine Associate With an Opioid for Sedation in ICU","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2011-10","conditions":"Sedation for Mechanical Ventilation","enrollment":164}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Rémifentamil + KETAMINE","genericName":"Rémifentamil + KETAMINE","companyName":"University Hospital, Clermont-Ferrand","companyId":"university-hospital-clermont-ferrand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Remifentanil and ketamine together provide rapid-onset anesthesia and analgesia by combining opioid mu-receptor agonism with NMDA receptor antagonism. Used for Procedural sedation and anesthesia, Induction of general anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}