{"id":"r-lh-supplementation","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Abdominal pain/bloating"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"r-LH is a recombinant form of the pituitary gonadotropin that binds to LH receptors on Leydig cells (in males) and theca cells (in females) to promote sex steroid synthesis. In males, it stimulates testosterone production; in females, it supports estrogen synthesis and ovulation. It is typically used in combination with FSH in assisted reproductive technology or in hypogonadotropic hypogonadism.","oneSentence":"Recombinant luteinizing hormone (r-LH) supplementation replaces or augments endogenous LH to stimulate testosterone production and support follicle development in reproductive disorders.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:03:35.897Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infertility in women undergoing assisted reproductive technology (ART)"},{"name":"Hypogonadotropic hypogonadism in males"},{"name":"Anovulation and ovulatory disorders in women"}]},"trialDetails":[{"nctId":"NCT06307184","phase":"","title":"Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer","status":"RECRUITING","sponsor":"Instituto Valenciano de Infertilidade de Lisboa","startDate":"2024-02-23","conditions":"Frozen Embryo Transfer","enrollment":530},{"nctId":"NCT05716139","phase":"NA","title":"Natural Cycle vs Programmed Cycle Frozen Embryo Transfer","status":"TERMINATED","sponsor":"Indira IVF Hospital Pvt Ltd","startDate":"2023-07-15","conditions":"Infertility, Frozen Embryo Transfer, Preeclampsia and Eclampsia","enrollment":172},{"nctId":"NCT02108223","phase":"PHASE4","title":"The Evaluation of Recombinant LH Supplementation in Patients With Suboptimal Response to Recombinant FSH Undergoing ICSI","status":"COMPLETED","sponsor":"Sisli Hamidiye Etfal Training and Research Hospital","startDate":"2009-01","conditions":"Infertility","enrollment":137},{"nctId":"NCT01016210","phase":"PHASE4","title":"The Effect of Luteinizing Hormone (LH) Supplementation Following Gonadotropin-releasing Hormone (GnRH) Antagonist Administration in Advanced Reproductive Ageing Women Undergoing IVF and Embryo Transfer (IVF/ET)","status":"COMPLETED","sponsor":"The Baruch Padeh Medical Center, Poriya","startDate":"2010-02","conditions":"Pregnancy Result Rape","enrollment":60},{"nctId":"NCT01339299","phase":"PHASE4","title":"Study to Examine Effect of Recombinant Luteinizing Hormone (r-Lh) and Recombinant Human Chorionic Gonadotropin (r-hCG) for Ovarian Stimulation in Assisted Reproduction Techniques (ART)","status":"COMPLETED","sponsor":"Regionshospitalet Viborg, Skive","startDate":"2009-10","conditions":"Controlled Ovarian Stimulation, Infertility","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["luveris"],"phase":"marketed","status":"active","brandName":"r-LH supplementation","genericName":"r-LH supplementation","companyName":"Sisli Hamidiye Etfal Training and Research Hospital","companyId":"sisli-hamidiye-etfal-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Recombinant luteinizing hormone (r-LH) supplementation replaces or augments endogenous LH to stimulate testosterone production and support follicle development in reproductive disorders. Used for Infertility in women undergoing assisted reproductive technology (ART), Hypogonadotropic hypogonadism in males, Anovulation and ovulatory disorders in women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}